New Cyanoarylporphyrazines with High Sensitivity of Photophysical Parameters to Viscosity as Promising Agents for Photodynamic Therapy

Photophysical properties and photodynamic activity for a series of cyanoarylporphyrazine pigments have been analyzed depending on the nature of the substituents and their position in the aromatic ring. Replacement of the fluorine atom in the para -position with the methoxy group leads to significant...

Full description

Saved in:
Bibliographic Details
Published inRussian journal of general chemistry Vol. 90; no. 2; pp. 249 - 256
Main Authors Lermontova, S. A., Lyubova, T. S., Ladilina, E. Yu, Plekhanov, V. I., Balalaeva, I. V., Boyarskii, V. P., Klapshina, L. G.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.02.2020
Springer Nature
Springer
Springer Nature B.V
Subjects
Aromatic compounds
Cancer
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Fluorine
Parameter sensitivity
Photochemotherapy
Photodynamic therapy
Physical Sciences
Pigments
Science & Technology
optical probes of intracellular viscosity
photosensitizers
photoinduced and dark cytotoxicity
fluorescent molecular rotors
cyanoarylporphyrazines
PORPHYRAZINES
Online AccessGet full text

Cover

More Information
Summary:Photophysical properties and photodynamic activity for a series of cyanoarylporphyrazine pigments have been analyzed depending on the nature of the substituents and their position in the aromatic ring. Replacement of the fluorine atom in the para -position with the methoxy group leads to significant increase in the ratio of the dark and photoinduced cytotoxicities, i.e. potential therapeutic index of porphyrazine as photosensitizer in photodynamic cancer therapy.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220020140