Taenia solium cysticercosis: immunity in pigs induced by primary infection

• Published in: Veterinary parasitology Vol. 81; no. 2; pp. 129 - 135
• Main Authors: de Aluja, A.S., Villalobos, A.N.M., Plancarte, A., Rodarte, L.F., Hernandez, M., Zamora, C., Sciutto, E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.02.1999
• Subjects: ACQUIRED CHARACTERS; Animals; ANTIBODIES; Antibodies, Helminth - blood; ANTICORPS; ANTICUERPOS; Brain - parasitology; CARACTERE ACQUIS; CARACTERES ADQUIRIDOS; CERDO; CISTICERCOSIS; CYSTICERCOSE; CYSTICERCOSIS; Cysticercosis - immunology; Cysticercosis - veterinary; Cysticercus - immunology; Humans; IMMUNISATION; IMMUNITE; IMMUNITY; IMMUNIZATION; Immunoenzyme Techniques - veterinary; INFECCION; INFECTION; INMUNIDAD; INMUNIZACION; Muscles - parasitology; Pig-cysticercosis; PORCIN; SWINE; Swine Diseases - immunology; TAENIA SOLIUM; Taenia solium immunity; Antibodies; Pig-cysticercosis; Taenia solium immunity
• ISSN: 0304-4017; 1873-2550
• DOI: 10.1016/S0304-4017(98)00234-9

The present study demonstrates that pigs experimentally infected with Taenia solium eggs develop resistance to reinfection that lasts at least five months. Thirteen 2-month-old piglets were infected with eggs of Taenia solium. After 5 months, two pigs were euthanized and five were challenged with eggs from a second tapeworm. Nine months after the first infection, six pigs were challenged with a third tapeworm. All 11 challenged pigs were euthanized 2 months after reinfection. In order to confirm the infectivity of the eggs, several piglets were inoculated with each taenia. Two of the five pigs reinfected after 5 months did not develop metacestodes, two showed few caseous non-infective forms and in the fifth pig, 14% of the metacestodes were vesicular and 86% colloidal and caseous. In the six animals challenged 9 months after the first infection, three were heavily infected with vesicular metacestodes and the other three showed only colloid and caseous forms in muscles. All parasites found in brains were vesicular. We conclude that immunity due to primary infection lasts at least 5 months. At 2 months of infection antigens of 24 and 39–42 kDa were the most frequently recognised. In those pigs with only a few caseous cysts in muscles and/or vesicular ones in brains no antibodies were detected.