Exosomes: Biogenesis, Composition, Functions, and Their Role in Pre-metastatic Niche Formation

• Published in: Biotechnology and bioprocess engineering Vol. 24; no. 5; pp. 689 - 701
• Main Authors: Patil, Anandrao Ashok, Rhee, Won Jong
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.09.2019; Springer Nature B.V; 한국생물공학회
• Subjects: Acid production; Acids; Acrylic resins; Alginates; Alginic acid; angiogenesis; Bacteria; Barium; Barium chloride; Beads; biogenesis; Biosynthesis; Biotechnology; Byproducts; carcinogenesis; Cations; cell communication; Cell density; Chemistry; Chemistry and Materials Science; Citric acid; E coli; Escherichia coli; exosomes; Fermentation; Fungi; Immobilization; immunity; Industrial and Production Engineering; Itaconic acid; Lipids; Metastasis; Monomers; nanoparticles; neoplasms; niches; Nucleic acids; proteins; Resins; Review Paper; Substrates; Superabsorbent polymers; 생물공학; pre-metastatic niche; exosomes; extracellular vesicles
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-019-0170-y

Exosomes are a subclass of extracellular vesicles that are released by normal or diseased cells. Exosomes are natural nanoparticles, contain natural cargo, including lipids, proteins, and nucleic acids, and are involved in intercellular communication. Exosomes are detected in the tumor microenvironment and participate in tumorigenesis by regulating angiogenesis, immunity, metastasis, and formation of pre-metastatic niches. This review mainly focuses on exosome biogenesis, composition, their biological and pathological functions, and roles in pre-metastatic niche formation.