The role of selenium added to pulmonary preservation solutions in isolated guinea pig lungs

An experimental comparative study on isolated guinea pig lungs has been undertaken to determine the probable beneficial effects of adding selenium to pulmonary preservation solutions in lung ischemia. The isolated lungs (n = 10 in each group) previously being perfused by oxygenated Krebs-Henseleit s...

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Published inThe Journal of thoracic and cardiovascular surgery Vol. 108; no. 5; pp. 922 - 927
Main Authors Soncul, Halim, Kaptanoglu, Melih, Oz, Eser, Halit, Velit, Bilgehan, Ayse, Cayci, Banu, Gokgoz, Levent, Turkozan, Nurten, Ersoz, Ali
Format Journal Article
LanguageEnglish
Published United States AATS/WTSA 01.11.1994
Subjects
Adenosine Deaminase - analysis
Animals
Guinea Pigs
Humans
Ischemia - metabolism
Ischemia - pathology
Lung - blood supply
Lung - drug effects
Male
Malondialdehyde - analysis
Organ Preservation - methods
Pulmonary Alveoli - pathology
Pulmonary Artery - physiology
Reperfusion Injury - metabolism
Reperfusion Injury - prevention & control
Selenium - pharmacology
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Abstract An experimental comparative study on isolated guinea pig lungs has been undertaken to determine the probable beneficial effects of adding selenium to pulmonary preservation solutions in lung ischemia. The isolated lungs (n = 10 in each group) previously being perfused by oxygenated Krebs-Henseleit solution were put in normothermic ischemic conditions just after the infusion of 30 ml of pulmonary preservation solution (Euro-Collins in the control group, Euro-Collins plus selenium 10(-3) mol in the experiment group). After 3 hours of normothermic ischemia the lungs were reperfused with the same buffer for 20 minutes. Pulmonary artery pressures, tissue malondialdehyde levels, and adenosine deaminase levels of the perfusate were measured before and after the ischemic period and also at the end of reperfusion. An electron microscopic analysis was performed on the lung tissues at the end of the experimental procedure. According to our data, the addition of selenium to pulmonary preservation solution showed a significant protective effect regarding both ischemic and reperfusion injury.
AbstractList An experimental comparative study on isolated guinea pig lungs has been undertaken to determine the probable beneficial effects of adding selenium to pulmonary preservation solutions in lung ischemia. The isolated lungs (n = 10 in each group) previously being perfused by oxygenated Krebs-Henseleit solution were put in normothermic ischemic conditions just after the infusion of 30 ml of pulmonary preservation solution (Euro-Collins in the control group, Euro-Collins plus selenium 10(-3) mol in the experiment group). After 3 hours of normothermic ischemia the lungs were reperfused with the same buffer for 20 minutes. Pulmonary artery pressures, tissue malondialdehyde levels, and adenosine deaminase levels of the perfusate were measured before and after the ischemic period and also at the end of reperfusion. An electron microscopic analysis was performed on the lung tissues at the end of the experimental procedure. According to our data, the addition of selenium to pulmonary preservation solution showed a significant protective effect regarding both ischemic and reperfusion injury.
Author Ersoz, Ali
Oz, Eser
Halit, Velit
Cayci, Banu
Gokgoz, Levent
Kaptanoglu, Melih
Turkozan, Nurten
Soncul, Halim
Bilgehan, Ayse
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Cites_doi 10.1007/BF01724689
10.1055/s-2007-1022176
10.1016/0306-3623(92)90303-2
10.1016/S0076-6879(78)52032-6
10.1097/00003246-198805000-00015
10.1016/S0022-5223(19)35034-2
10.1378/chest.84.1.51
10.1126/science.179.4073.588
10.1016/S0022-5223(19)35061-5
10.1016/S0140-6736(69)90753-3
10.1016/S0022-5223(19)34232-1
10.1016/0021-9150(88)90109-8
10.1056/NEJM198501173120305
10.1016/S0022-5223(19)34378-8
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SubjectTerms Adenosine Deaminase - analysis
Animals
Guinea Pigs
Humans
Ischemia - metabolism
Ischemia - pathology
Lung - blood supply
Lung - drug effects
Male
Malondialdehyde - analysis
Organ Preservation - methods
Pulmonary Alveoli - pathology
Pulmonary Artery - physiology
Reperfusion Injury - metabolism
Reperfusion Injury - prevention & control
Selenium - pharmacology
Title The role of selenium added to pulmonary preservation solutions in isolated guinea pig lungs
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