Akirin2 expression in response to vaccine-induced immunity in chicken

Akirin2 is a nuclear factor that plays an important role in the development and regulation of innate immune response. In this study, akirin2 gene expression in several primary immune organs (liver, thymus, and bursa) of Hi-Line Brown chicken administered with the LoSota vaccine was analyzed during t...

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Published inGenetics and molecular research Vol. 14; no. 4; pp. 17489 - 17495
Main Authors Man, C L, Mu, W T, Chang, Y, Zhao, D X
Format Journal Article
LanguageEnglish
Published Brazil 21.12.2015
Subjects
Animals
Antibodies, Viral - genetics
Antibodies, Viral - immunology
Chickens
Cloning, Molecular
Immunity - drug effects
Immunity, Innate - genetics
Newcastle disease virus
Paramyxoviridae
Repressor Proteins - biosynthesis
Repressor Proteins - genetics
Vaccines - genetics
Vaccines - immunology
Zinc Fingers - genetics
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Summary:Akirin2 is a nuclear factor that plays an important role in the development and regulation of innate immune response. In this study, akirin2 gene expression in several primary immune organs (liver, thymus, and bursa) of Hi-Line Brown chicken administered with the LoSota vaccine was analyzed during the various stages of increase in Newcastle disease virus antibody titer. The results revealed that akirin2 expression was significantly higher in the liver (P < 0.01) and bursa (P < 0.05) of vaccinated chicken 7 and 14 days post-immunization, respectively. These results could serve as a foundation for further studies on the functions of akirin2 in immune response.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1676-5680
1676-5680
DOI:10.4238/2015.December.21.20