Hyaluronic Acid-based Biomimetic Hydrogels for Tissue Engineering and Medical Applications

• Published in: Biotechnology and bioprocess engineering Vol. 26; no. 4; pp. 503 - 516
• Main Authors: An, Soohwan, Choi, Soojeong, Min, Sungjin, Cho, Seung-Woo
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.08.2021; Springer Nature B.V; 한국생물공학회
• Subjects: Biocompatibility; biocompatible materials; Biodegradability; Biodegradation; Biological properties; Biomaterials; Biomedical materials; Biomimetics; Biomolecules; bioprocessing; Biotechnology; Cellular structure; Chemical modification; Chemistry; Chemistry and Materials Science; Extracellular matrix; Fabrication; Functional groups; Hyaluronic acid; Hydrogels; Immunogenicity; Industrial and Production Engineering; Invited Review Paper; medicine; Polymers; Regenerative medicine; Tissue engineering; 생물공학; biomimetic hydrogel; tissue engineering; biomedical applications; hyaluronic acid
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-020-0343-8

Hyaluronic acid (HA), an essential component of extracellular matrix (ECM), plays an important role in various cellular activities, including migration, proliferation, and differentiation. Not only its structural and biological properties, but also properties such as biocompatibility, biodegradability, and low immunogenicity make HA a promising biomaterial for tissue engineering and regenerative medicine. HA has been widely utilized as a hydrogel to form complex polymer networks, which can be chemically modified owing to the abundance of functional groups. To closely recapitulate native tissues, many approaches have been developed through chemical modification, incorporation of various biomaterials and biomolecules based on biomimetics, and fabrication techniques. Thus, HA-based hydrogels can be designed to exhibit specific properties or functions for targeted tissues, capable of maintaining or replacing structural and biological properties. This review highlights recent efforts in developing HA-based hydrogels as ECM-mimetic scaffolds and bio-inspired functional biomaterials in the fields of tissue engineering and regenerative medicine as well as their medical applications.