Adverse reactions to iodinated contrast media

Adverse reactions to iodinated contrast media (ICM) are more likely to develop in patients with asthma, a history of allergy or contrast reaction and in those who are debilitated or medically unstable. These reactions can be divided into renal and general, and the latter are subdivided into acute an...

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Bibliographic Details
Published inEuropean radiology Vol. 11; no. 7; pp. 1267 - 1275
Main Authors Morcos, S K, Thomsen, H S
Format Journal Article
LanguageEnglish
Published Germany Springer Nature B.V 01.01.2001
Subjects
Acidosis, Lactic - chemically induced
Acids
Asthma
Atoms & subatomic particles
Contrast agents
Contrast Media - administration & dosage
Contrast Media - adverse effects
Contrast Media - pharmacokinetics
Diabetes
Drug Hypersensitivity - etiology
Drug Hypersensitivity - prevention & control
Drug Hypersensitivity - therapy
Edema
Hematology
Humans
Hypoglycemic Agents - adverse effects
Injections
Iodine
Iodine - administration & dosage
Iodine - adverse effects
Iodine - pharmacokinetics
Kidney Diseases - chemically induced
Kidneys
Metformin - adverse effects
Osmolar Concentration
Pharmacokinetics
Plasma
Toxicity
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Summary:Adverse reactions to iodinated contrast media (ICM) are more likely to develop in patients with asthma, a history of allergy or contrast reaction and in those who are debilitated or medically unstable. These reactions can be divided into renal and general, and the latter are subdivided into acute and delayed. Acute general reactions can be minor, intermediate or severe. Fatal reactions are rare. The introduction of low-osmolality agents has caused an overall reduction in the number of non-fatal contrast reactions. Prompt recognition and treatment of acute adverse side effects to ICM is invaluable and may prevent a reaction from becoming severe. Familiarity with cardiopulmonary resuscitation is essential for successful management of life-threatening reactions. Contrast-media-induced renal impairment can be reduced with the use of low-osmolality contrast media and extracellular volume expansion. The use of ICM in diabetic patients receiving metformin should be carried out with care to avoid metformin-induced lactic acidosis. However, this problem is mainly observed in patients with diabetic nephropathy.
ISSN:0938-7994
1432-1084
DOI:10.1007/s003300000729