Synthesis and Anticancer Evaluation of Amide Derivatives of 1,3,4-Oxadiazole Linked with Benzoxazole

A novel series of amide 1,3,4-oxadiazole linked benzoxazole derivatives 12a–12j are synthesized and their anticancer activity is screened against four human cancer cell lines including A549 (Lung cancer), MCF7 (Breast cancer), A375 (Melanoma cancer), HT-29 (Colon cancer) using Combretastatin-A4 as a...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 89; no. 5; pp. 1003 - 1008
Main Authors Ravinaik, B., Ramachandran, D., Rao, M. V. Basaveswara
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.05.2019
Springer Nature
Springer
Springer Nature B.V
Subjects
Anticancer properties
Antifungal agents
Cancer
Care and treatment
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Colon
Colon cancer
Derivatives
Heterocyclic compounds
Lung cancer
Oxadiazoles
Physical Sciences
Prevention
Science & Technology
Synthesis
benzoxazole
amide
AJI9561
zibotentan
1,3,4-oxadiazole and anticancer activity
DESIGN
4-oxadiazole and anticancer activity
ANALOGS
MOLECULAR DOCKING
1
3
BIOLOGICAL EVALUATION
BENZIMIDAZOLES
BINDING
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Summary:A novel series of amide 1,3,4-oxadiazole linked benzoxazole derivatives 12a–12j are synthesized and their anticancer activity is screened against four human cancer cell lines including A549 (Lung cancer), MCF7 (Breast cancer), A375 (Melanoma cancer), HT-29 (Colon cancer) using Combretastatin-A4 as a control drug. Among the synthesized compounds, 12c and 12g demonstrate potent anticancer activity against HT-29 cancer cell line with IC 50 values of 0.018 and 0.093 µM, respectively, which is higher than the standard drug.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219050219