Physicochemical Properties and Structure of the Bone Matrix in Simulated Tuberculous Osteitis

The physicochemical properties and structure of the bone matrix are studied in a case of simulated tuberculous osteitis without treatment and after a full course of specific antibacterial therapy. Using X-ray diffraction, infrared spectroscopy, thermal analysis, and scanning electron microscopy, we...

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Bibliographic Details
Published inTechnical physics Vol. 64; no. 1; pp. 121 - 126
Main Authors Krut’ko, V. K., Kazbanov, V. V., Musskaya, O. N., Gaidash, A. A., Kulak, A. I., Chekan, N. M., Serdobintsev, M. S., Skrotskaya, K. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.01.2019
Springer
Springer Nature B.V
Subjects
60 APPLIED LIFE SCIENCES
ABSORPTION SPECTROSCOPY
Analysis
Antibacterial agents
APATITES
Biocompatibility
Biomedical materials
Biomedical Physics
Calcium phosphate
CALCIUM PHOSPHATES
CARBONATES
CHEMICAL PROPERTIES
Classical and Continuum Physics
CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY
CRYSTAL GROWTH
CRYSTAL LATTICES
CRYSTALS
DETRITUS
Disintegration
Electron microscopy
EMBRITTLEMENT
Hydroxyapatite
Hydroxyapatites
Infrared analysis
INFRARED SPECTRA
Infrared spectroscopy
Microscopy
Phosphates
PHYSICAL PROPERTIES
Physics
Physics and Astronomy
Properties (attributes)
SCANNING ELECTRON MICROSCOPY
SKELETON
Spectroscopy
Surgical implants
THERAPY
THERMAL ANALYSIS
Tuberculosis
X-RAY DIFFRACTION
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Summary:The physicochemical properties and structure of the bone matrix are studied in a case of simulated tuberculous osteitis without treatment and after a full course of specific antibacterial therapy. Using X-ray diffraction, infrared spectroscopy, thermal analysis, and scanning electron microscopy, we revealed that tuberculous osteitis causes fine disintegration of the bone matrix due to an increase in nonstoichiometric hydroxyapatite, formation of amorphous calcium phosphates, and a decrease of the organic phase, which is accompanied by embrittlement of the bone matrix. Excessive growth of carbonate-hydroxyapatite crystals of a mixed AB substitution type leads to excessive osteogenesis, accompanied by the uncontrolled growth of bone trabeculae. The presence of “liming” regions in the crystal lattice of hydroxyapatite increases the “binding” properties of the bone matrix in which mycobacteria are immobilized and removed in the composition of detritus.
ISSN:1063-7842
1090-6525
DOI:10.1134/S1063784219010183