Stereoselective synthesis and applications of spirocyclic oxindoles

The development of novel synthetic strategies to form new chemical entities in a stereoselective manner is an ongoing significant objective in organic and medicinal chemistry. This review analyses the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3- to 8-membered...

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Bibliographic Details
Published inOrganic chemistry frontiers an international journal of organic chemistry Vol. 8; no. 5; pp. 1026 - 1084
Main Authors Boddy, Alexander J, Bull, James A
Format Journal Article
LanguageEnglish
Published London Royal Society of Chemistry 09.03.2021
Subjects
Enantiomers
Intermediates
Organic chemistry
Pharmaceutical sciences
Stereoselectivity
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Summary:The development of novel synthetic strategies to form new chemical entities in a stereoselective manner is an ongoing significant objective in organic and medicinal chemistry. This review analyses the development of new stereoselective approaches to spirocyclic oxindoles with spiro-3- to 8-membered rings. It highlights the importance of these structures for applications in medicinal chemistry, as intermediates or final products in total synthesis and as model compounds for the development of enantioselective catalytic methodologies.
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ISSN:2052-4110
2052-4110
DOI:10.1039/d0qo01085e