Evaluation of Mechanical and Thermal Properties of Hydroxyapatite-levan Composite Bone Graft

• Published in: Biotechnology and bioprocess engineering Vol. 26; no. 2; pp. 201 - 207
• Main Authors: Song, Younghoon, Joo, Kye, Seo, Jeong Hyun
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.04.2021; Springer Nature B.V; 한국생물공학회
• Subjects: Adhesives; Biodegradability; Biodegradable materials; Biodegradation; Biomedical materials; Biotechnology; Bone cements; Bone grafts; Bone growth; Bone implants; bone transplantation; Cement; Chemistry; Chemistry and Materials Science; Composite materials; Grafting; Grafts; Hydroxyapatite; Industrial and Production Engineering; Levan; Mechanical properties; Polymethyl methacrylate; Polymethylmethacrylate; Regeneration; Regeneration (physiology); Research Paper; Scaffolds; Skin & tissue grafts; strength (mechanics); Substitute bone; Thermal properties; Thermodynamic properties; Tissue engineering; 생물공학; hydroxyapatite; bone graft; levan; sintering; composite scaffold
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-020-0094-6

Biodegradable materials have been received great attention as bone graft substitutes for bone regeneration and tissue engineering. However, their low mechanical property remains a major challenge for the use in load-bearing applications. Here, we developed mechanically reinforced composite scaffold containing adhesive levan as a binder for sintered hydroxyapatite (sHAp) and then examined the mechanical and thermal properties of the composite scaffold. We found that sHAp-levan composite scaffold exhibited remarkably enhanced mechanical strength, which is similar to that of polymethyl methacrylate (PMMA) bone cement. This composite scaffold can be utilized as a promising bone graft for bone regeneration and tissue engineering.