Small-molecule fluorescence-based probes for interrogating major organ diseases
Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related...
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| Published in | Chemical Society reviews Vol. 5; no. 17; pp. 9391 - 9429 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Royal Society of Chemistry
07.09.2021
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate
in vitro
and
in vivo
biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes
in vitro
and
in vivo
. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases.
This tutorial review describes recent advances involving small molecule fluorescent probes designed to aid in the study of major organ diseases. |
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| Bibliography: | Hai-Hao Han is a postdoctoral research fellow working under the supervision of Prof. Xiao-Peng He at School of Chemistry and Molecular Engineering, ECUST. His research interests in the development of new fluorescent probes for disease diagnosis and active analyte detection. Jia Li received his PhD from SIMM in 2000 and was promoted to professor in 2005. He stayed at the University of Cambridge (UK, February 2003-August 2003) and Garvan Institute of Medical Research (Australia, August 2004-February 2005) as a visiting scholar. He received the China National Fund for Distinguished Young Scientists in 2011. From 2019 he has served as the director of SIMM. He Tian Jr. is a PhD student in Applied Chemistry under the supervision of Prof. Xiao-Peng He from East China University of Science and Technology. His research interests include synthesis and biological studies of novel fluorescent probes. Jonathan L. Sessler received a BSc degree in chemistry in 1977 from the University of California, Berkeley. He obtained his PhD from Stanford University in 1982. After postdoctoral stays in Strasbourg and Kyoto, he accepted a position at the University of Texas at Austin, where he is currently the Doherty-Welch Chair. He was also a WCU Professor at Yonsei University and from 2016-2020 held a part-time laboratory directorate at Shanghai University. He was a co-founder of Pharmacyclics, Inc. His latest technology is the basis for a new company, Oncotex, Inc. Yi Zang is professor at SIMM (CAS). Her research mainly focuses on the biological research of AMPK and development of new chemical probes. Adam C. Sedgwick is a postdoctoral research fellow working under the supervision of Prof. Jonathan L. Sessler at The University of Texas in Austin. His research interests are in the realms of stimuli-responsive materials, molecular imaging agents, and theranostic agents. Xiao-Peng He is a professor at the Feringa Nobel Prize Scientists Joint Research Center, School of Chemistry and Molecular Engineering, ECUST. He obtained his BSc (2006) and PhD (2011) from ECUST. He completed a co-tutored doctoral program at ENS Cachan (France) (2008 to 2009) and postdoctoral research with Kaixian Chen (SIMM, CAS) from 2011 to 2013 at ECUST. Tony D James is a Professor at The University of Bath and Fellow of the Royal Society of Chemistry. He was awarded the Daiwa-Adrian Prize (2013), Inaugural CASE Prize (2015), MSMLG Czarnik Award (2018) and currently holds a prestigious Royal Society Wolfson Research Merit Award (2017-2022). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/d0cs01183e |