Omics in Myopia

Myopia is a globally emerging issue, with multiple medical and socio-economic burdens and no well-established causal treatment thus far. A better insight into altered biochemical pathways and underlying pathogenesis might facilitate early diagnosis and treatment of myopia, ultimately leading to the...

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Published inJournal of clinical medicine Vol. 9; no. 11; p. 3464
Main Authors Grochowski, Emil Tomasz, Pietrowska, Karolina, Kowalczyk, Tomasz, Mariak, Zofia, Kretowski, Adam, Ciborowski, Michal, Dmuchowska, Diana Anna
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 28.10.2020
MDPI
Subjects
Cataracts
Clinical medicine
Metabolism
Metabolites
Pathogenesis
Proteomics
Retina
Retinal detachment
Review
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Summary:Myopia is a globally emerging issue, with multiple medical and socio-economic burdens and no well-established causal treatment thus far. A better insight into altered biochemical pathways and underlying pathogenesis might facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and therapeutic measures. In this review, we summarize current data about the metabolomics and proteomics of myopia in humans and present various experimental approaches and animal models, along with their strengths and weaknesses. We also discuss the potential applicability of these findings to medical practice and suggest directions for future research.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9113464