Recent development in computer simulations of lipid bilayers

Rapid development of computer power during the last decade has made molecular simulations of lipid bilayers feasible for many research groups, which, together with the growing general interest in investigations of these very important biological systems has lead to tremendous increase of the number...

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Bibliographic Details
Published inSoft matter Vol. 7; no. 1; pp. 25 - 39
Main Authors Lyubartsev, Alexander P, Rabinovich, Alexander L
Format Journal Article
LanguageEnglish
Published 01.01.2011
Subjects
Cholesterol
Coarsening
Computation
Computer simulation
Covering
Inclusions
Lipids
Mathematical models
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Summary:Rapid development of computer power during the last decade has made molecular simulations of lipid bilayers feasible for many research groups, which, together with the growing general interest in investigations of these very important biological systems has lead to tremendous increase of the number of research on the computational modeling of lipid bilayers. In this review, we give account of the recent progress in computer simulations of lipid bilayers covering mainly the period of the last 5 years, and covering several selected subjects: development of the force fields for lipid bilayer simulations, studies of the role of lipid unsaturation, the effect of cholesterol and other inclusions on properties of the bilayer, and use of coarse-grained models. We review recent progress in computer simulations of lipid bilayers, covering questions of force field development, simulations of bilayers with unsaturated lipids, cholesterol and other inclusions, and use of coarse-grained models
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ISSN:1744-683X
1744-6848
1744-6848
DOI:10.1039/c0sm00457j