Lamotrigine-associated anticonvulsant hypersensitivity syndrome

We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; ra...

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Bibliographic Details
Published inNeurology Vol. 51; no. 4; p. 1172
Main Authors Schlienger, R G, Knowles, S R, Shear, N H
Format Journal Article
LanguageEnglish
Published United States 01.10.1998
Subjects
Adolescent
Adult
Aged
Anticonvulsants - adverse effects
Child
Child, Preschool
Drug Hypersensitivity - diagnosis
Epilepsy - drug therapy
Female
Humans
Lamotrigine
Male
Middle Aged
Triazines - adverse effects
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Summary:We systematically reviewed and analyzed published and unpublished cases of lamotrigine-associated adverse drug reactions consistent with the features of the anticonvulsant hypersensitivity syndrome (AHS) to identify characteristics of the syndrome. We identified 26 cases (mean age, 28+/-18 years; range, 3.5 to 74 years; 54% female), of which nine were published. The characteristics of the syndrome associated with lamotrigine are comparable to AHS induced by older aromatic anticonvulsants.
ISSN:0028-3878
DOI:10.1212/wnl.51.4.1172