Synthesis, Processing and the Effect of Thermal Treatment on the Solubility, Antioxidant Potential and Cytocompatibility of Y2O3 and CeO2 doped SiO2-SrO-Na2O Glass-Ceramics

Thermal treatment of a 0.52SiO -0.24SrO-0.24 Na O- MO glass-ceramic series (where = 0.08 and MO = Y O or CeO ) was conducted in order to synthesize yttrium (Y ) and cerium (Ce ) crystalline species that may act as radical oxygen specie (ROS) scavengers. The prominent phase for the is a sodium-stront...

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Published inJournal of biomaterials applications p. 8853282221078448
Main Authors Placek, Lana M, Keenan, Timothy J, Coughlan, Aisling, Wren, Anthony W
Format Journal Article
LanguageEnglish
Published England 01.07.2022
Subjects
bioceramic
bioactive glass
yttrium
antioxidant capacity
cerium
nerve
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Summary:Thermal treatment of a 0.52SiO -0.24SrO-0.24 Na O- MO glass-ceramic series (where = 0.08 and MO = Y O or CeO ) was conducted in order to synthesize yttrium (Y ) and cerium (Ce ) crystalline species that may act as radical oxygen specie (ROS) scavengers. The prominent phase for the is a sodium-strontium-silicate while the experimental glass-ceramics ( , , and present sodium-Y/Ce-silicate and oxide phases. Disk shrinkage during thermal processing ranges from 1-7% for , , , and in both diameter and thickness. Solubility studies determined that the release of Si and Na are greatest from the disks which peaks at 1550 µg/mL. Release from the Y and Ce glass-ceramics reached 320 µg/mL for Si and 630 µg/mL for Na . The range of antioxidant capacity (ABTS assay) for all samples was 0.31-3.9 mMTE. No significant reduction in MC 3T3 Osteoblast cell viability was observed for any composition tested.
ISSN:1530-8022
DOI:10.1177/08853282221078448