Genome-Wide Association Analysis of Reproductive Traits in Chinese Holstein Cattle

• Published in: Genes Vol. 15; no. 1; p. 12
• Main Authors: Liu, Jiashuang, Xu, Lingyang, Ding, Xiangbin, Ma, Yi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2024
• Subjects: Animals; Association analysis; Ca2+/calmodulin-dependent phosphodiesterase; Cattle; Cattle - genetics; Chromosomes; Dairy cattle; Female; Genes; Genetic testing; Genome-wide association studies; Genome-Wide Association Study - veterinary; Genomes; Genomics; Milk production; Phenotype; Pregnancy; Pregnancy Rate; Quality control; Reproduction - genetics; Single-nucleotide polymorphism; Software; Stat1 protein; Stillbirth; China; Chinese Holstein cattle; genome-wide association study; reproductive traits
• ISSN: 2073-4425; 2073-4425
• DOI: 10.3390/genes15010012

This study was to explore potential SNP loci for reproductive traits in Chinese Holstein cattle and identify candidate genes. Genome-wide Association Study based on mixed linear model was performed on 643 Holstein cattle using GeneSeek Bovine 50 K SNP chip. Our results detected forty significant SNP loci after Bonferroni correction. We identified five genes ( and ) as being associated with pregnancy ratio of young cows, five genes ( and ) as being associated with pregnancy ratio of adult cows, and nine genes ( , and ) as being associated with daughter pregnancy rate. Our study may provide valuable insights into identifying genes related to reproductive traits and help promote the application of molecular breeding in dairy cows.