Disease-miRNAdb: a manually-curated database for the investigation of the microRNA-human disease relationship

• Published in: Genes & genomics Vol. 39; no. 12; pp. 1419 - 1424
• Main Authors: Shin, Jae Moon, Lim, Wooyoung, Lee, Kyung-Mi, Won, Jung Im, Jung, Da Woon, Nho, Chu Won, Kang, Kui Dong, Yoon, Jee Hee, Cho, Yoon Shin
• Format: Journal Article
• Language: English
• Published: Seoul The Genetics Society of Korea 01.12.2017; Springer Nature B.V; 한국유전학회
• Subjects: Animal Genetics and Genomics; Association analysis; Biomedical and Life Sciences; Cancer; cell biology; Disease; Gene expression; gene interaction; Genetic diversity; genetic variation; human diseases; Human Genetics; human population; Internet; kidney diseases; Kidney transplantation; Life Sciences; metabolic diseases; Microbial Genetics and Genomics; microRNA; miRNA; neoplasms; nucleotides; Plant Genetics and Genomics; Post-transcription; Research Article; Single-nucleotide polymorphism; 생물학; MicroRNA target gene; Database; MicroRNA; Single nucleotide polymorphism; Diseases
• ISSN: 1976-9571; 2092-9293
• DOI: 10.1007/s13258-017-0628-2

MicroRNAs (miRNA) of approximately 22 nucleotides are fundamental molecules in cellular biology that act by modulating target gene expression. As a post-transcriptional/translational regulator, the role of miRNAs in human disease is highly expected. Recently, a rising number of miRNAs that are associated with a variety of human diseases have been reported in the literature. Aiming to provide a comprehensive of resource of miRNAs that are related to the human disease, we built the Disease miRNA Database (Disease-miRNAdb). MiRNAs from three groups of diseases including kidney disease, cancer, and metabolic disease were manually curated in the current version of database located on a user-friendly online website ( http://disease-miRNAdb.hallym.ac.kr ). In addition, this database also includes information regarding single nucleotide polymorphisms (SNPs) located in pre-miRNAs, miRNA flanking regions, and 3′-UTRs of miRNA target genes. The generation of genetic variation in these regions may result in a loss or gain of miRNA-target gene interactions, which may influence the development of disease. Thus, information regarding miRNA-related SNPs will be useful in the discovery of disease-associated miRNAs in human populations by employing SNP association analysis for the disease of interest. Disease-miRNAdb will be continually maintained with up-to-date information to provide a current and valuable resource for investigating the roles of miRNAs in human disease.