The applications of atomic force microscopy to vision science

The atomic force microscope (AFM) is widely used in materials science and has found many applications in biological sciences but has been limited in use in vision science. The AFM can be used to image the topography of soft biological materials in their native environments. It can also be used to pr...

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Bibliographic Details
Published inInvestigative ophthalmology & visual science Vol. 51; no. 12; pp. 6083 - 6094
Main Authors Last, Julie A, Russell, Paul, Nealey, Paul F, Murphy, Christopher J
Format Journal Article
LanguageEnglish
Published United States Association for Research in Vision and Ophthalmology, Inc 01.12.2010
Subjects
Animals
Biomedical Research
Eye - metabolism
Eye Diseases - metabolism
Eye Proteins - metabolism
Humans
Microscopy, Atomic Force - instrumentation
Microscopy, Atomic Force - methods
Ophthalmology - instrumentation
Ophthalmology - methods
Reviews
Surface Properties
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Summary:The atomic force microscope (AFM) is widely used in materials science and has found many applications in biological sciences but has been limited in use in vision science. The AFM can be used to image the topography of soft biological materials in their native environments. It can also be used to probe the mechanical properties of cells and extracellular matrices, including their intrinsic elastic modulus and receptor-ligand interactions. In this review, the operation of the AFM is described along with a review of how it has been thus far used in vision science. It is hoped that this review will serve to stimulate vision scientists to consider incorporating AFM as part of their research toolkit.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1552-5783
0146-0404
1552-5783
DOI:10.1167/iovs.10-5470