Radiation-Induced Mouse Leukemia: Consistent Occurrence of an Extra and a Marker Chromosome

Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen...

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Published inScience (American Association for the Advancement of Science) Vol. 143; no. 3608; pp. 810 - 813
Main Authors Wald, Niel, Upton, Arthur C., Jenkins, Vernon K., Borges, Wayne H.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 21.02.1964
Subjects
Animals
Blood
Bone marrow
Bone Marrow Cells
Cell nucleolus
Chromosome Aberrations
Chromosomes
Leukemia
Leukemia, Radiation-Induced
Lymphocytes
Mice
Myeloid leukemia
Spleen
Spleen cells
Viruses
X-Rays
CHROMOSOME ABNORMALITIES
MICE
LEUKEMIA, RADIATION-INDUCED
EXPERIMENTAL LAB STUDY
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Summary:Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen cells or with cell-free ultracentrifugates. This suggests that the changes in the chromosomes are caused by a virus.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.143.3608.810