Age-related loss of cannabinoid receptor binding sites and mRNA in the rat striatum

Differences in the distribution of cannabinoid receptor (studied by receptor binding radioautography using the synthetic psychoactive cannabinoid ligand [3H]CP55,940) and its mRNA (studied by in situ hybridization histochemistry using oligonucleotide probes complementary to rat cannabinoid receptor...

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Bibliographic Details
Published inNeuroscience letters Vol. 147; no. 2; p. 179
Main Authors Mailleux, P, Vanderhaeghen, J J
Format Journal Article
LanguageEnglish
Published Ireland 07.12.1992
Subjects
Aging - metabolism
Analgesics - pharmacology
Animals
Autoradiography
Corpus Striatum - anatomy & histology
Corpus Striatum - metabolism
Cyclohexanols - pharmacology
DNA Probes
In Situ Hybridization
In Vitro Techniques
Male
Rats
Rats, Wistar
Receptors, Cannabinoid
Receptors, Drug - metabolism
RNA, Messenger - metabolism
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Summary:Differences in the distribution of cannabinoid receptor (studied by receptor binding radioautography using the synthetic psychoactive cannabinoid ligand [3H]CP55,940) and its mRNA (studied by in situ hybridization histochemistry using oligonucleotide probes complementary to rat cannabinoid receptor cDNA) have been investigated in the rat striatum during ageing. The striata of old rats (24 months) show a 50% reduction in expression of cannabinoid receptors and mRNA levels when compared with young (3 months) equivalents. Thus, changes in cannabinoid receptor gene expression appear to be partially responsible for age-related loss of these receptors.
ISSN:0304-3940
DOI:10.1016/0304-3940(92)90589-Y