Simulation of the growth of neurospheres

Under appropriate conditions, the neural stem cells are able to proliferate and to form suspended neurospheres containing stem cells and neuronal and glial progenitors in different stages of differentiation. Our lattice Monte Carlo simulations, taking into account the effect of spatial constraints a...

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Bibliographic Details
Published inEurophysics letters Vol. 68; no. 1; pp. 134 - 140
Main Authors Zhdanov, V. P, Kasemo, B
Format Journal Article
LanguageEnglish
Published IOP Publishing 01.10.2004
EDP Sciences
Subjects
05.40.-a
87.18.Hf
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Summary:Under appropriate conditions, the neural stem cells are able to proliferate and to form suspended neurospheres containing stem cells and neuronal and glial progenitors in different stages of differentiation. Our lattice Monte Carlo simulations, taking into account the effect of spatial constraints and cell-cell adhesion on cell diffusion and division, show that i) the neurosphere-size distribution is very broad and ii) the spatial distribution of various cells inside neurospheres is heterogeneous.
Bibliography:istex:B8E9049D4834EF02B17B3BA07FB60241AA84A9E3
ark:/67375/80W-LJPDG073-X
publisher-ID:epl8384
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0295-5075
1286-4854
DOI:10.1209/epl/i2004-10170-1