Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice

Porcine reproductive and respiratory syndrome virus （PRRSV） is a major pathogen that causes reproductive failure and respiratory disease in pigs, resulting in devastating economic losses worldwide. Porcine alveolar macrophages （PAMs） are the primary target cells of PRRSV , and the putative receptors...

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Published inScience bulletin Vol. 62; no. 24; pp. 1634 - 1636
Main Authors Cui, Zhengzhi, Niu, Shuaishuai, Liu, Jingjing, Xu, Lei, Dai, Yunping, Li, Ning, Kang, Youmin, Zhang, Linlin, Zhou, Lei, Yu, Shuyang
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 30.12.2017
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Summary:Porcine reproductive and respiratory syndrome virus （PRRSV） is a major pathogen that causes reproductive failure and respiratory disease in pigs, resulting in devastating economic losses worldwide. Porcine alveolar macrophages （PAMs） are the primary target cells of PRRSV , and the putative receptors, including CD163, CD169, and CD151, play key roles during infection . However, the understanding of PRRSV infection and pathogenesis is limited by its narrow host range. Pig is the unparalleled animal susceptible to PRRSV, but not well-suited for the study of long-term chronic infection or immune response in vivo because of their long breed- ing cvcle, size, high cost, and lack of biological materials.
Bibliography:Over-expression of CD163, CD169; CD151 is not sufficient;improve the susceptibility to porcine
Porcine reproductive and respiratory syndrome virus （PRRSV） is a major pathogen that causes reproductive failure and respiratory disease in pigs, resulting in devastating economic losses worldwide. Porcine alveolar macrophages （PAMs） are the primary target cells of PRRSV , and the putative receptors, including CD163, CD169, and CD151, play key roles during infection . However, the understanding of PRRSV infection and pathogenesis is limited by its narrow host range. Pig is the unparalleled animal susceptible to PRRSV, but not well-suited for the study of long-term chronic infection or immune response in vivo because of their long breed- ing cvcle, size, high cost, and lack of biological materials.
10-1298/N
ISSN:2095-9273
2095-9281
DOI:10.1016/j.scib.2017.11.020