Genetic polymorphisms of glutathione S-transferases M1 and T1 modulate hematological changes of individuals chronically exposed to natural sour gas

In order to find the effect of genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and GSTT1 on hematological changes of individuals chronically exposed to natural sour gas, the present study was done. Study subjects (59 males, 55 females) were residents of contaminated areas of Masjid-i-S...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 324; no. 2; pp. 584 - 587
Main Author Saadat, Mostafa
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 12.11.2004
Subjects
Blood Platelets - metabolism
Female
Fossil Fuels - toxicity
Genetic polymorphism
Genotype
Glutathione Transferase - genetics
Glutathione Transferase - metabolism
GSTM1
GSTT1
Hematocrit
Hematological parameters
Hemoglobins - metabolism
Humans
Iran
Linear Models
Male
Natural sour gas
Polymerase Chain Reaction
Polymorphism, Genetic
Sulfur - toxicity
Sulfur compounds
Iran
Sulfur compounds
Natural sour gas
GSTT1
GSTM1
Hematological parameters
Genetic polymorphism
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ISSN0006-291X
1090-2104
DOI10.1016/j.bbrc.2004.09.090

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Summary:In order to find the effect of genetic polymorphisms of glutathione S-transferase M1 (GSTM1) and GSTT1 on hematological changes of individuals chronically exposed to natural sour gas, the present study was done. Study subjects (59 males, 55 females) were residents of contaminated areas of Masjid-i-Sulaiman (southwest of Iran). The GSTM1 and GSTT1 genotypes were determined using a polymerase chain reaction-based method. The multiple linear regression method was applied. There is significant association between GSTs genotypes and either hemoglobin (t=2.185, P=0.031) or hematocrit (t=2.454, P=0.016). Also there is weak association between GSTs genotypes and WBC counts (t=1.802, P=0.074). The hemoglobin and hematocrit levels and WBC counts increased in individuals who had null genotypes of GSTM1 and GSTT1 compared to subjects with one or two active genes. Also the levels of hemoglobin and hematocrit and WBC counts increased in persons with one active genotype compared to subjects who had two active genes. There is no significant association between neither platelet nor WBC differential parameters and GSTs genotypes.
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ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.09.090