Isoflavones with neuroprotective activities from fruits of Cudrania tricuspidata

• Published in: Phytochemistry (Oxford) Vol. 111; pp. 141 - 148
• Main Authors: Nguyen Tuan Hiep, Kwon, Jaeyoung, Kim, Dong-Woo, Hwang, Bang Yeon, Lee, Hak-Ju, Mar, Woongchon, Lee, Dongho
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 01.03.2015
• Subjects: Biochemistry & Molecular Biology; Cell Death - drug effects; Fruit - chemistry; Humans; Isoflavones - chemistry; Isoflavones - isolation & purification; Isoflavones - pharmacology; Life Sciences & Biomedicine; Molecular Structure; Moraceae - chemistry; Neuroprotective Agents - chemistry; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; Nuclear Magnetic Resonance, Biomolecular; Oxidopamine - pharmacology; Plant Roots - chemistry; Plant Sciences; Science & Technology; Neuroprotection; Parkinson's disease; Human neuroblastoma SH-SY5Y; COMPONENTS; 6-OHDA; FLAVONOIDS; Moraceae; ISOPRENYLATED XANTHONES; SEEDS; PRENYLATED ISOFLAVONOIDS; ERYTHRINA; Cudrania tricuspidata; ROOT BARK; CYTOTOXICITY; Isoflavones; CONSTITUENTS; Parkinson’s disease
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2014.10.021

Ten isoflavones, cudraisoflavones B-K (1-10), together with 27 known isoflavones, were isolated from the EtOAc soluble extract of fruits of Cudrania tricuspidata. The structures of compounds 1-10 were elucidated on the basis of MS and NMR spectroscopic data, including 2D NMR experiments. Compounds 7-9 and three known (11-13) compounds showed neuroprotective activity against 6-hydroxydopamine induced cell death in human neuroblastoma SH-SY5Y cells, with EC50 values of 0.5-9.2 mu M. (C) 2014 Elsevier Ltd. All rights reserved.