Hypothyroidism as a correlate of lateral ventricular enlargement in manic-depressive and neurotic illness

Lateral ventricular size, as assessed by computed tomography, was not significantly greater in manic-depressive cases than in neurotic patients, but 19% of manic-depressive cases had ventricular brain ratios (VBR) more than two standard deviations above the neurotic mean. Few correlates of VBR were...

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Bibliographic Details
Published inBritish journal of psychiatry Vol. 148; p. 317
Main Authors Johnstone, E C, Owens, D G, Crow, T J, Colter, N, Lawton, C A, Jagoe, R, Kreel, L
Format Journal Article
LanguageEnglish
Published England 01.03.1986
Subjects
Aged
Anthropometry
Bipolar Disorder - complications
Bipolar Disorder - drug therapy
Brain - diagnostic imaging
Cerebral Ventriculography
Female
Humans
Hypothyroidism - complications
Lithium - therapeutic use
Male
Middle Aged
Neurotic Disorders - complications
Neurotic Disorders - drug therapy
Schizophrenia - complications
Tomography, X-Ray Computed
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Summary:Lateral ventricular size, as assessed by computed tomography, was not significantly greater in manic-depressive cases than in neurotic patients, but 19% of manic-depressive cases had ventricular brain ratios (VBR) more than two standard deviations above the neurotic mean. Few correlates of VBR were found in the features of the illness and the treatment given, apart from the fact that in the outpatient sample, there was a significant association between increased VBR and hypothyroidism. Hypothyroidism was relatively common in this sample, but was treated and not associated with cognitive impairment. There was no relationship between lithium administration and VBR.
ISSN:0007-1250
DOI:10.1192/bjp.148.3.317