Purslane Extract and Glucose Homeostasis in Adults with Type 2 Diabetes: A Double-Blind, Placebo-Controlled Clinical Trial of Efficacy and Safety

• Published in: Journal of medicinal food Vol. 19; no. 2; pp. 133 - 140
• Main Authors: Wainstein, Julio, Landau, Zohar, Dayan, Yosefa Bar, Jakubowicz, Daniela, Grothe, Torsten, Perrinjaquet-Moccetti, Tania, Boaz, Mona
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.02.2016
• Subjects: Adult; adults; Aged; Blood Glucose - metabolism; Blood Pressure - drug effects; clinical trials; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Dose-Response Relationship, Drug; Double-Blind Method; Female; females; glucose; Glycated Hemoglobin A - metabolism; glycemic control; homeostasis; Homeostasis - drug effects; Humans; hypoglycemic agents; Hypoglycemic Agents - administration & dosage; lipids; Male; medicinal plants; Middle Aged; noninsulin-dependent diabetes mellitus; normal values; patients; placebos; Plant Extracts - administration & dosage; Portulaca - chemistry; Portulaca oleracea; systolic blood pressure; traditional medicine; randomized clinical trial; purslane; type 2 diabetes
• ISSN: 1557-7600; 1557-7600
• DOI: 10.1089/jmf.2015.0090

Purslane extract (PE) is derived from Portulaca oleracea L., a medicinal plant used in traditional medicine for its antidiabetic properties. This randomized, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PE in improving glucose control, blood pressure, and lipid profile in adults with type 2 diabetes mellitus (T2DM) treated with a single oral hypoglycemic agent at baseline. Subjects were randomized to treatment with three capsules of PE/day or a matched placebo. Change from baseline to the week 12 end-of-follow-up visit measures of glucose homeostasis, hemodynamics, and lipid profile was compared by treatment assignment. In addition, these measures were evaluated in a subgroup of “responders,” defined as patients whose week 12 HbA1c was lower than baseline values, regardless of treatment assignment. This group was further assessed in subgroups of baseline oral hypoglycemic treatment. A total of 63 participants were treated with either PE (n = 31, 11 females, mean age 52.4 ± 7.9 years) or matched placebo (n = 32, 11 females, mean age 58.3 ± 10.8 years). In the total cohort, systolic blood pressure declined significantly more in the PE group than the placebo group: −7.5 ± 5.0 versus −0.01 ± 0.3 mmHg, P < .0001. In the responders' subgroup, HbA1c declined significantly more in the PE group than the placebo group: −0.8% ± 0.4% versus −0.6% ± 0.5%, P = .03. Few adverse events were reported. These were mild and did not differ by treatment assignment. PE appears to be a safe, adjunct treatment for T2DM, significantly reducing systolic blood pressure in the total cohort and HbA1c in the subgroup of responders.