Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycles

Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compound...

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 89; no. 4; pp. 806 - 812
Main Authors Shehta, W., Abdel Hamid, A. M.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.04.2019
Springer Nature
Springer
Springer Nature B.V
Subjects
Antibacterial agents
Antifungal agents
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
Physical Sciences
Pyrimidines
Reagents
Science & Technology
heterocyclization
pyrimidotriazine
pyrimidotriazepine
triazolopyrimidine
cyclocondensation
DESIGN
DERIVATIVES
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Summary:Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219040273