Preparation and properties of a novel thermosensitive N-trimethyl chitosan hydrogel

• Published in: Polymer bulletin (Berlin, Germany) Vol. 63; no. 4; pp. 531 - 545
• Main Authors: Chang, Yuhua, Xiao, Ling, Du, Yumin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.10.2009; Springer; Springer Nature B.V
• Subjects: Applied sciences; Biological and medical sciences; Biomedical materials; Body temperature; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chitosan; Complex Fluids and Microfluidics; Exact sciences and technology; General pharmacology; Glycerophosphate; Human body; Hydrogels; Low temperature; Medical sciences; Natural polymers; NMR; Nuclear magnetic resonance; Organic Chemistry; Organic polymers; Original Paper; Peptides; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physical Chemistry; Physicochemistry of polymers; Polymer Sciences; Polymers; Properties and characterization; Rheological properties; Rheology; Soft and Granular Matter; Solution and gel properties; Spectrum analysis; Starch and polysaccharides; Viscoelasticity; Viscosity; United States > US; trimethyl chitosan; Hydrogel; Thermosensitivity; Controlled release; Swelling; Control release polymer; Temperature effect; Drug carrier; Glycerophosphate; Serum albumin; Experimental study; Protein; Polyelectrolyte; Chitosan derivatives; Morphology; Preparation; Oside polymer; Release; Quaternary ammonium polymer; Rheological properties

A novel injectable thermosensitive hydrogel system composed of N -trimethyl chitosan chloride (TMC) and β-glycerophosphate (β-GP), coded as TMC/β-GP, was designed. The morphology and rheological behavior of hydrogels were characterized by scanning electron microscopy and rheometer, respectively. The...