Preparation and properties of a novel thermosensitive N-trimethyl chitosan hydrogel

• Published in: Polymer bulletin (Berlin, Germany) Vol. 63; no. 4; pp. 531 - 545
• Main Authors: Chang, Yuhua, Xiao, Ling, Du, Yumin
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.10.2009; Springer; Springer Nature B.V
• Subjects: Applied sciences; Biological and medical sciences; Biomedical materials; Body temperature; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Chitosan; Complex Fluids and Microfluidics; Exact sciences and technology; General pharmacology; Glycerophosphate; Human body; Hydrogels; Low temperature; Medical sciences; Natural polymers; NMR; Nuclear magnetic resonance; Organic Chemistry; Organic polymers; Original Paper; Peptides; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physical Chemistry; Physicochemistry of polymers; Polymer Sciences; Polymers; Properties and characterization; Rheological properties; Rheology; Soft and Granular Matter; Solution and gel properties; Spectrum analysis; Starch and polysaccharides; Viscoelasticity; Viscosity; United States > US; trimethyl chitosan; Hydrogel; Thermosensitivity; Controlled release; Swelling; Control release polymer; Temperature effect; Drug carrier; Glycerophosphate; Serum albumin; Experimental study; Protein; Polyelectrolyte; Chitosan derivatives; Morphology; Preparation; Oside polymer; Release; Quaternary ammonium polymer; Rheological properties
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-009-0103-6

A novel injectable thermosensitive hydrogel system composed of N -trimethyl chitosan chloride (TMC) and β-glycerophosphate (β-GP), coded as TMC/β-GP, was designed. The morphology and rheological behavior of hydrogels were characterized by scanning electron microscopy and rheometer, respectively. Their swelling properties were carefully studied. The results revealed that the TMC/β-GP system was liquid with low viscosity at low temperature, which allowed it to be an ideal injectable material for biomedical applications. It was interesting that the system kept in liquid status for a long time near 4 °C and transformed rapidly to gel status within 1 min upon heating to 37 °C. The hydrogel could be dissolved at acid pH, while it absorbed water at neutral and basic conditions. The release of BSA from TMC/β-GP gels was slow at neutral pH. The TMC/β-GP hydrogel is a promising vehicle for the drug release, tissue repairing and regeneration.