Effects of Polyphenol-Rich Chokeberry Juice on Antioxidant/Pro-Oxidant Status in Healthy Subjects

• Published in: Journal of medicinal food Vol. 17; no. 8; pp. 869 - 874
• Main Authors: Kardum, Nevena, Konić-Ristić, Aleksandra, Šavikin, Katarina, Spasić, Slavica, Stefanović, Aleksandra, Ivanišević, Jasmina, Miljković, Milica
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.08.2014
• Subjects: Adult; anthocyanins; antioxidants; Antioxidants - metabolism; Beverages - analysis; biomarkers; Blood Pressure; body mass index; fat body; Female; females; Food, Organic - analysis; Fruit - metabolism; Healthy Volunteers; Humans; juices; lipid peroxidation; long term effects; Middle Aged; optimal nutrition; Oxidants - metabolism; Oxidative Stress; phytopharmaceuticals; polyphenols; Polyphenols - metabolism; protective effect; Prunus - metabolism; Reactive Oxygen Species - metabolism; small fruits; Thiobarbituric Acid Reactive Substances - metabolism; thiobarbituric acid-reactive substances; volunteers; waist circumference; women; antioxidant; TBARS; polyphenol; chokeberry; women
• ISSN: 1557-7600; 1557-7600
• DOI: 10.1089/jmf.2013.0135

Berry fruits are a rich source of polyphenols, especially anthocyanins: well-known potent anti-oxidant phytochemicals. The purpose of this study was to evaluate beneficial effects of long-term consumption of polyphenol-rich organic chokeberry juice on different markers of antioxidant/pro-oxidant status in healthy female volunteers. Twenty-nine women, aged 25–49, were included in the study. Serological markers of oxidative stress and antioxidant defence, blood pressure, routine biochemical, and anthropometric parameters were analyzed at baseline and after twelve weeks of regular chokeberry juice consumption. Significant decrease in thiobarbituric acid-reactive substances level (TBARS; P<.001) and pro-oxidant-antioxidant balance (PAB; P<.05), as well as increase in paroxonase-1 activity toward diazoxon (P<.01) were found. Total oxidative status and sulphydryl groups levels were not significantly influenced by the intervention. Anthropometric, biochemical parameters, and blood pressure values were within the referent values for all subjects and were not influenced by the chokeberry juice consumption. However, we found positive correlation between age, body mass index, waist circumference, body fat percent, blood pressure, and analyzed marker of lipid peroxidation, which was influenced by the consumption. In conclusion, the fine modulation of several antioxidant/pro-oxidant status biomarkers observed in healthy subjects indicates putative prophylactic effects of polyphenol-rich chokeberry juice and supports its importance as part of an optimal diet.