PhotoCORMs: CO release moves into the visible

The potential of carbon monoxide to act as a therapeutic agent is now well-established. Controlled delivery of CO is best achieved using 'CORMs': molecules which release known amounts of carbon monoxide in response to a stimulus. Metal carbonyl complexes will release CO if irradiated with...

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Published inDalton transactions : an international journal of inorganic chemistry Vol. 45; no. 16; pp. 681 - 6811
Main Authors Wright, Mark A, Wright, Joseph A
Format Journal Article
LanguageEnglish
Published England 28.04.2016
Subjects
Carbon monoxide
Carbon Monoxide - chemistry
Chemical compounds
Cobalt
Coordination compounds
Light
Metal carbonyls
Organic Chemicals - chemistry
Origins
Pharmacology
Photochemical Processes
Ultraviolet
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Summary:The potential of carbon monoxide to act as a therapeutic agent is now well-established. Controlled delivery of CO is best achieved using 'CORMs': molecules which release known amounts of carbon monoxide in response to a stimulus. Metal carbonyl complexes will release CO if irradiated with ultraviolet light, but it is only in the past five years that development of true 'photoCORMs' has been explored. Recent exciting developments in this area now show that design of photoCORMs operating well into the visible region is achievable. In this Perspective, we examine the growth of photoCORMs from their origins in the photophysics of metal carbonyls to the latest visible-light agents. The potential of carbon monoxide to act as a therapeutic agent is now well-established. In this Perspective, we examine the growth of photoCORMs from their origins in the photophysics of metal carbonyls to the latest visible-light agents.
Bibliography:Mark A. Wright obtained a first class Masters in Chemistry from the University of East Anglia in 2013, writing his Masters dissertation on amine adducts of mono(pentafluorophenyl)borane and dehydrocoupling intermediates using group four metallocenes. He then began his PhD developing carbon monoxide releasing molecules as potential therapeutic agents.
Joseph Wright obtained his PhD degree from the University of Cambridge in 2003 working on the mechanism of the Wacker reaction under the supervision of Dr Jonathan Spencer. He then undertook postdoctoral positions at the University of Southampton (2003-2004 in the group of Dr Andreas Danopoulos) and at UEA (2005-2008 with Professor Manfred Bochmann and 2008-2012 with Professor Christopher Pickett). In 2012 he was appointed as Lecturer in Energy Materials at the University of East Anglia, and has interests in organometallic chemistry, reaction mechanism and DFT modelling.
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ISSN:1477-9226
1477-9234
DOI:10.1039/c5dt04849d