Noninvasive measurement of glucose concentration on human fingertip by optical coherence tomography

• Published in: Journal of biomedical optics Vol. 23; no. 4; p. 047001
• Main Authors: Chen, Tseng-Lin, Lo, Yu-Lung, Liao, Chia-Chi, Phan, Quoc-Hung
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.04.2018
• Subjects: optical coherence tomography; differential Mueller matrix polarimetry; noninvasive glucose sensing
• ISSN: 1083-3668; 1560-2281
• DOI: 10.1117/1.JBO.23.4.047001

A method is proposed for determining the glucose concentration on the human fingertip by extracting two optical parameters, namely the optical rotation angle and the depolarization index, using a Mueller optical coherence tomography technique and a genetic algorithm. The feasibility of the proposed method is demonstrated by measuring the optical rotation angle and depolarization index of aqueous glucose solutions with low and high scattering, respectively. It is shown that for both solutions, the optical rotation angle and depolarization index vary approximately linearly with the glucose concentration. As a result, the ability of the proposed method to obtain the glucose concentration by means of just two optical parameters is confirmed. The practical applicability of the proposed technique is demonstrated by measuring the optical rotation angle and depolarization index on the human fingertip of healthy volunteers under various glucose conditions.