Synthesis and Evaluation of Antibacterial Activity of 1,2,4-Oxadiazole-Containing Biphenylcarboxylic Acids

A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus .

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Bibliographic Details
Published inRussian journal of general chemistry Vol. 90; no. 9; pp. 1611 - 1619
Main Authors Tarasenko, M. V., Presnukhina, S. I., Baikov, S. V., Shetnev, A. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.09.2020
Springer Nature
Springer
Springer Nature B.V
Subjects
Analysis
Antibacterial agents
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Chemistry/Food Science
E coli
Escherichia coli
Oxadiazoles
Physical Sciences
Science & Technology
Synthesis
dicarboxylic acid anhydrides
antimicrobial activity
heterocycles
amidoximes
basic catalysis
DESIGN
ONE-POT SYNTHESIS
PERIPHERY
OXADIAZOLE CLASS
ANTIBIOTIC-RESISTANCE
COMBINATION
IN-VITRO
DOUBLE-BLIND
INHIBITORS
DERIVATIVES
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Summary:A one-pot method for the synthesis of biphenylcarboxylic acids containing 1,2,4-oxadiazole ring in the NaOH–DMSO system was developed. The results of in vitro experiments showed that the synthesized compounds exhibit antibacterial activity against susceptible strains of E. coli and S. aureus .
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220090042