Inhibitory Effects of Honokiol and Magnolol on Biofilm Formation by Acinetobacter baumannii

• Published in: Biotechnology and bioprocess engineering Vol. 24; no. 2; pp. 359 - 365
• Main Authors: Khadke, Sagar Kiran, Lee, Jin-Hyung, Woo, Je-Tae, Lee, Jintae
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.03.2019; Springer Nature B.V; 한국생물공학회
• Subjects: Acinetobacter baumannii; antimicrobial properties; biofilm; Biofilms; Biological activity; Biotechnology; Caenorhabditis elegans; Cancer; Cell death; Chemistry; Chemistry and Materials Science; cross infection; CXCL12 protein; CXCR4 protein; Desiccation; Ganciclovir; Gene expression; Glioma cells; Heart; Heart diseases; Hematopoiesis; Herpes simplex; honokiol; Hypoxia; Industrial and Production Engineering; Kinases; Magnetic resonance imaging; magnolol; Medical equipment; Molecular chains; Monitoring; Myocardial infarction; Nosocomial infection; pathogens; Positron emission tomography; Reporter gene; Research Paper; Stem cell transplantation; Stem cells; Swine; Thymidine; Thymidine kinase; tissues; Viruses; Worms; 생물공학; biofilm formation; motility; honokiol; magnolol; pellicle
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-019-0006-9

Acinetobacter baumannii is a nosocomial pathogen that can survive unfavorable conditions, such as, desiccation, nutrient starvation, and antimicrobial treatment, and this is primarily due to its ability to form biofilms on biotic and abiotic surfaces like tissues and medical devices. In this study, honokiol and magnolol were investigated for antibiofilm activity against A. baumannii ATCC 17978. Both were found to inhibit biofilm formation dose-dependently and to disperse matured biofilms. Honokiol and magnolol were found to inhibit biofilm formation by five and four of eight additional clinical A. baumannii isolates, respectively. Furthermore, honokiol and magnolol effectively suppressed pellicle formation and the surface motilities of the A. baumannii and prolonged the survival of infected nematode Caenorhabditis elegans. These results demonstrate that honokiol and magnolol may be useful for controlling A. baumannii infections.