Sex and estrogen influence drug abuse

• Published in: Trends in pharmacological sciences (Regular ed.) Vol. 25; no. 5; pp. 273 - 279
• Main Authors: Carroll, Marilyn E., Lynch, Wendy J., Roth, Megan E., Morgan, Andrew D., Cosgrove, Kelly P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2004
• Subjects: Animals; Behavior, Animal; Conditioning, Operant - drug effects; Conditioning, Operant - physiology; Diet; Disease Models, Animal; Estrogens - physiology; Ethanol - pharmacokinetics; Female; Humans; Locomotion - drug effects; Male; Sex Characteristics; Substance-Related Disorders - etiology; Substance-Related Disorders - physiopathology; Substance-Related Disorders - therapy

Evidence is accumulating that the etiology, epidemiology, consequences and mechanisms that underlie drug abuse are different in males and females. In this review, we present examples of sex differences in all phases of drug abuse, including acquisition, steady-state maintenance, escalation, dysregul...