Peritoneum and Tissues of the Female Reproductive Tract as Physiological Sources of CA-125

The origin of physiological CA-125 serum levels, which in normally menstruating women were shown to depend on their actual menstrual cycle phase, has not yet been completely elucidated. It is furthermore conceivable that physiological CA-125 sources may contribute to serum elevations in the various...

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Bibliographic Details
Published inTumor biology Vol. 19; no. 4; pp. 275 - 282
Main Authors Zeimet, Alain G., Offner, Felix A., Müller-Holzner, Elisabeth, Widschwendter, Martin, Abendstein, Burghard, Fuith, Lothar C., Daxenbichler, Günter, Marth, Christian
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 1998
Springer Nature B.V
Subjects
Adult
Biological and medical sciences
Biomarkers, Tumor - analysis
Biomarkers, Tumor - blood
CA-125 Antigen - analysis
CA-125 Antigen - blood
Epithelium - metabolism
Female
Host-tumor relations. Immunology. Biological markers
Humans
Interleukin-1 - metabolism
Medical sciences
Menstrual Cycle - metabolism
Original Paper
Ovary - chemistry
Ovary - metabolism
Peritoneum - chemistry
Peritoneum - metabolism
Tumor Necrosis Factor-alpha - metabolism
Tumors
Tumor marker
Ovary
Mesothelial cells
Cytokines
Menstrual cycle
CA-125
Ovarian surface epithelium
Endometrium
Human
Carbohydrate antigen
Mesothelium
Tumor associated antigen
Biosynthesis
Tumoral marker
Female genital system
CA 125 antigen
Epithelial cell
Reproductive system
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Summary:The origin of physiological CA-125 serum levels, which in normally menstruating women were shown to depend on their actual menstrual cycle phase, has not yet been completely elucidated. It is furthermore conceivable that physiological CA-125 sources may contribute to serum elevations in the various pathologies associated with increased circulating CA-125. The present review deals with menstrual cycle-dependent expression of CA-125 in normal tissues of the female reproductive tract in relation to the actual circulating CA-125 levels together with in vivo data concerning the inductive effect of medroxyprogesterone acetate on circulating CA-125 studied in 24 postmenopausal women. Furthermore, in vitro results on constitutive, steroid hormone- and cytokine-modulated CA-125 shedding from human peritoneal mesothelial and ovarian surface epithelial cells are summarized.
Bibliography:ObjectType-Article-1
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ISSN:1010-4283
1423-0380
DOI:10.1159/000030018