Combating bioterrorism with personal computers

Using personal computers in a grid is permitting the in silico screening of millions of molecules to seek out potential inhibitors of agents that pose bioterror threats. Current projects are targeting anthrax and smallpox, but the approach has many attractions for investigating any known protein tar...

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Bibliographic Details
Published inJournal of molecular graphics & modelling Vol. 22; no. 6; pp. 473 - 478
Main Authors Richards, W.Graham, Grant, Guy H., Harrison, Karl N.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2004
Subjects
Amino Acid Sequence
Anthrax - prevention & control
Bioterrorism
Bioterrorism - prevention & control
Computational Biology - methods
DNA Topoisomerases, Type I - chemistry
Drug Design
Humans
In silico screening
Microcomputers
Models, Theoretical
Molecular Sequence Data
Personal computers
Protein Structure, Tertiary
Sequence Alignment
Smallpox - prevention & control
In silico screening
Bioterrorism
Personal computers
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Summary:Using personal computers in a grid is permitting the in silico screening of millions of molecules to seek out potential inhibitors of agents that pose bioterror threats. Current projects are targeting anthrax and smallpox, but the approach has many attractions for investigating any known protein target and its inhibition.
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ISSN:1093-3263
1873-4243
DOI:10.1016/j.jmgm.2004.03.007