Acute and late damage in the mouse small intestine following multiple fractionations of neutrons or X-rays

The neutron RBE for acute intestinal damage as measured by decrease in the intestine DNA content and the LD 50 5 following whole-body exposure of mice is compared with the RBE for late effects in this organ. Late damage, primarily fibrosis, ulceration, perforation, and obstruction, was produced by i...

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Published inInternational journal of radiation oncology, biology, physics Vol. 2; no. 7; pp. 693 - 696
Main Authors Geraci, J.P., Jackson, K.L., Christensen, G.M., Thrower, P.D., Weyer, B.J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1977
Subjects
Acute effects
Animals
Female
Fractionation
Intestinal Diseases - etiology
Intestine
Intestine, Small
Late effects
Lethal Dose 50
Mice
Neutrons
Radiation Dosage
Radiation Injuries, Experimental - etiology
RBE
Time Factors
X-Rays
Neutrons
Late effects
Fractionation
RBE
Acute effects
Intestine
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Summary:The neutron RBE for acute intestinal damage as measured by decrease in the intestine DNA content and the LD 50 5 following whole-body exposure of mice is compared with the RBE for late effects in this organ. Late damage, primarily fibrosis, ulceration, perforation, and obstruction, was produced by irradiating a segment of the intestine. A significant sparing effect of fractionation was observed for all forms of gut injury with neutrons and X-rays. However, there was less sparing with neutron-induced injury, resulting in an increase in RBE with fractionation. The RBE for late effects changed more rapidly than the RBE for acute effects. This resulted in a significantly larger RBE for late effects relative to acute effects as the neutron dose per fraction approached that used clinically.
ISSN:0360-3016
1879-355X
DOI:10.1016/0360-3016(77)90049-9