Should Race-Genotype Interactions Be Considered in the Global Development of CYP2C19 Substrates? A Proposed Framework Using Physiologically Based Pharmacokinetic Modeling

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Bibliographic Details
Published inJournal of clinical pharmacology Vol. 57; no. 4; p. 417
Main Authors Patel, Chirag, Rathi, Chetan, Venkatakrishnan, Karthik
Format Journal Article
LanguageEnglish
Published England 01.04.2017
Subjects
Continental Population Groups - genetics
Cytochrome P-450 CYP2C19 - genetics
Cytochrome P-450 CYP2C19 - metabolism
Cytochrome P-450 CYP2C19 Inducers - metabolism
Cytochrome P-450 CYP2C19 Inducers - pharmacology
Cytochrome P-450 CYP2C19 Inhibitors - metabolism
Cytochrome P-450 CYP2C19 Inhibitors - pharmacology
Drug Discovery - methods
Drug Discovery - trends
Genotype
Humans
Models, Biological
Substrate Specificity - drug effects
Substrate Specificity - physiology
PBPK
race
CYP2C19
genetic polymorphism
physiologically based pharmacokinetic modeling
genotype
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ISSN:1552-4604
DOI:10.1002/jcph.859