Consequences of gastrointestinal surgery on drug absorption

Gastrointestinal (GI) surgery associated with resection or bypass can affect the absorption and kinetics of certain drugs. The goal of this article is 3-fold: (1) highlight the physiologic changes associated with selected GI surgeries (specifically gastric, small intestine, and colon), (2) review th...

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Bibliographic Details
Published inNutrition in clinical practice Vol. 28; no. 4; p. 429
Main Authors Titus, Rachel, Kastenmeier, Andrew, Otterson, Mary F
Format Journal Article
LanguageEnglish
Published United States 01.08.2013
Subjects
Digestive System Surgical Procedures - adverse effects
Gastric Bypass - adverse effects
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - surgery
Humans
Intestine, Small - metabolism
Pharmaceutical Preparations - metabolism
Postoperative Complications
pharmacokinetics
bariatric surgery
short bowel syndrome
digestive system surgical procedures
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Summary:Gastrointestinal (GI) surgery associated with resection or bypass can affect the absorption and kinetics of certain drugs. The goal of this article is 3-fold: (1) highlight the physiologic changes associated with selected GI surgeries (specifically gastric, small intestine, and colon), (2) review the implications for drug and nutrient absorption, and (3) suggest modifications of the pharmacologic agents, dosing regimens, and routes of delivery. Few large trials are available to use as references, but there is a wealth of individual reports and small series. Understanding the predictable challenges of drug administration in these patients will improve care.
ISSN:1941-2452
DOI:10.1177/0884533613490740