Annexin A2 extracellular translocation and virus interaction: A potential target for antivirus‐drug discovery

• Published in: Reviews in medical virology Vol. 29; no. 3; pp. e2038 - n/a
• Main Authors: Aliyu, Isah Abubakar, Ling, King‐Hwa, Md Hashim, Nurfariesha, Chee, Hui‐Yee
• Format: Journal Article
• Language: English
• Published: England Wiley Periodicals Inc 01.05.2019
• Subjects: Actin; Animals; Annexin A2; Annexin A2 - metabolism; Calcium; Cell Membrane - metabolism; Cytoplasm; Cytoskeleton; Drug discovery; drug‐target; Host-Pathogen Interactions; Humans; Localization; Membrane proteins; Membranes; Phospholipids; Plants; Receptors, Virus - metabolism; Translocation; Virus Assembly; Virus Physiological Phenomena; Virus Release; Virus Replication; Viruses; virus‐interaction; virus-interaction; translocation; Annexin A2; drug-target
• ISSN: 1052-9276; 1099-1654
• DOI: 10.1002/rmv.2038

Summary Annexin A2 is a membrane scaffolding and binding protein, which mediated various cellular events. Its functions are generally affected by cellular localization. In the cytoplasm, they interacted with different phospholipid membranes in Ca2+‐dependent manner and play vital roles including actin binding, remodeling and dynamics, cytoskeletal rearrangement, and lipid‐raft microdomain formation. However, upon cell exposure to certain stimuli, annexin A2 translocates to the external leaflets of the plasma membrane where annexin A2 was recently reported to serve as a virus receptor, play an important role in the formation of virus replication complex, or implicated in virus assembly and budding. Here, we review some of annexin A2 roles in virus infections and the potentiality of targeting annexin A2 in the design of novel and promising antivirus agent that may have a broader consequence in virus therapy.