BACE1 influences debris clearance and axonal regeneration in injured peripheral nerve

During 3 years, my research activities in Jack Griffin's laboratory focused on the influence of β‐amyloid precursor protein cleaving enzyme 1 (BACE1) on the degeneration/regeneration of sciatic nerve of mice. Here, potential mechanisms of how BACE1 enzymatic activity influences these processes...

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Bibliographic Details
Published inJournal of the peripheral nervous system Vol. 17; no. s3; pp. 30 - 33
Main Author Farah, Mohamed H.
Format Journal Article
LanguageEnglish
Published Malden, USA Wiley Periodicals, Inc 01.12.2012
Wiley Subscription Services, Inc
Subjects
Alzheimer's disease
Amyloid Precursor Protein Secretases - metabolism
Animals
APP
Aspartic Acid Endopeptidases - metabolism
BACE1
beta -Amyloid
beta -Site APP cleaving enzyme 1
Degeneration
Enzymatic activity
injured nerve
Mice
Nerve Regeneration - physiology
neuregulin
Peripheral nerves
Peripheral Nerves - metabolism
Phagocytosis - physiology
Proenzymes
Regeneration
Sciatic nerve
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Summary:During 3 years, my research activities in Jack Griffin's laboratory focused on the influence of β‐amyloid precursor protein cleaving enzyme 1 (BACE1) on the degeneration/regeneration of sciatic nerve of mice. Here, potential mechanisms of how BACE1 enzymatic activity influences these processes are discussed.
Bibliography:Robert Packard Center for ALS Research
istex:6950FB12C4A1B9A38E23B1CA3E394D25D5E5E6D1
ark:/67375/WNG-KKFSNZ1S-5
ArticleID:JNS5428
Muscular Dystrophy Association
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
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ObjectType-Review-3
ISSN:1085-9489
1529-8027
1529-8027
DOI:10.1111/j.1529-8027.2012.00428.x