Electrochemical Synthesis of 5‐Selenouracil Derivatives by Selenylation of Uracils

A simple and efficient electrochemical selenylation of uracils in the presence of NH4I for the synthesis of 5‐selenouracils has been developed. This transformation was performed in the transition metal‐free, oxidant‐free, and aerobic conditions, providing a rapid and practical protocol to 5‐selenour...

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Bibliographic Details
Published inEuropean journal of organic chemistry Vol. 2020; no. 28; pp. 4384 - 4388
Main Authors Wang, Qian, Ma, Xian‐Li, Chen, Yan‐Yan, Jiang, Cai‐Na, Xu, Yan‐Li
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 02.08.2020
Wiley Subscription Services, Inc
Subjects
Chemical synthesis
Chemistry
Chemistry, Organic
Derivatives
Electrochemistry
Nucleobases
Oxidizing agents
Physical Sciences
Science & Technology
Selenium
Synthetic methods
Transition metals
Uracil
CROSS-LINK FORMATION
ELECTROSYNTHESIS
C-SE
NUCLEOSIDES
SULFONYLATION
N BOND
Nucleobases
CASCADE REACTION
ORGANOSELENIUM
PYRIMIDINE
Electrochemistry
Synthetic methods
Selenium
Uracil
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Summary:A simple and efficient electrochemical selenylation of uracils in the presence of NH4I for the synthesis of 5‐selenouracils has been developed. This transformation was performed in the transition metal‐free, oxidant‐free, and aerobic conditions, providing a rapid and practical protocol to 5‐selenouracil derivatives. A simple and efficient electrochemical selenylation of uracils in the presence of NH4I for the synthesis of 5‐selenouracils has been developed. This transformation was performed in the transition metal‐free, oxidant‐free, and air conditions, providing a rapid and practical protocol to 5‐selenouracil derivatives.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202000637