Deuterium labeling of methyl 1,1,1,3,3,3-hexafluoroisopropyl ether

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 39; no. 5; pp. 387 - 393
• Main Authors: Baker, Max T., Ronnenberg, William C., Ruzicka, Jan A., Tinker, John H.
• Format: Journal Article
• Language: English
• Published: Chichester John Wiley & Sons, Ltd 01.05.1997; Wiley
• Subjects: acetic acid-D; Aliphatic compounds; Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry; Chemistry, Analytical; Chemistry, Medicinal; dechlorination; deuteration; deuterium; Exact sciences and technology; Life Sciences & Biomedicine; methyl hexafluoroisopropyl ether; Organic chemistry; Pharmacology & Pharmacy; Physical Sciences; Preparations and properties; Science & Technology; deuteration; METABOLISM; RAT; deuterium; methyl hexafluoroisopropyl ether; acetic acid-D; dechlorination; DEUTERATED SEVOFLURANE; Deuterium; Chemical reduction; Dechlorination; Isotope labelling; Aliphatic compound; Zinc Chlorides; Fluorine Organic compounds; Haloether; Acetic acid; Chemical synthesis; Deuteriation; Zinc
• ISSN: 0362-4803; 1099-1344
• DOI: 10.1002/(SICI)1099-1344(199705)39:5<387::AID-JLCR975>3.0.CO;2-6

Trideuteromethyl 1,1,1,3,3,3‐hexafluoroisopropyl ether was synthesized by the reductive dechlorination of trichloromethyl 1,1,1,3,3,3‐hexafluoro‐isopropyl ether. This reaction was performed by zinc/zinc chloride catalyzed reduction in acetic acid‐D. This reaction yielded 80% methyl 1,1,1,3,3,3‐hexafluoroisopropyl ether consisting of approximately 70% trideuteromethyl 1,1,1,3,3,3‐hexafluoroisopropyl ether and 26% dideuteromethyl 1,1,1,3,3,3‐hexafluoro‐isopropyl ether. © 1997 John Wiley & Sons, Ltd.