Human granulosa cells contain insulin-like growth factor-binding protein (IGF BP-1) mRNA

Previous studies have demonstrated expression of insulin-like growth factor-binding protein (IGF BP-1) in secretory and decidualized endometrium, in adult and fetal liver, and in HepG2 liver cancer cells. We have studied the expression of IGF BP-1 in various types of ovarian neoplasias, normal ovary...

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Published inClinical endocrinology (Oxford) Vol. 32; no. 5; p. 635
Main Authors Koistinen, R, Suikkari, A M, Tiitinen, A, Kontula, K, Seppälä, M
Format Journal Article
LanguageEnglish
Published England 01.05.1990
Subjects
Adult
Aged
Carrier Proteins - genetics
Cells, Cultured
Female
Gene Expression
Granulosa Cells - metabolism
Humans
In Vitro Techniques
Insulin-Like Growth Factor Binding Proteins
Middle Aged
Molecular Weight
Nucleic Acid Hybridization
Ovarian Neoplasms - metabolism
Ovary - metabolism
RNA, Messenger - analysis
RNA, Messenger - metabolism
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Summary:Previous studies have demonstrated expression of insulin-like growth factor-binding protein (IGF BP-1) in secretory and decidualized endometrium, in adult and fetal liver, and in HepG2 liver cancer cells. We have studied the expression of IGF BP-1 in various types of ovarian neoplasias, normal ovary, and granulosa cells from hyperstimulated human ovarian follicles by RNA blot hybridization. A single 1.6 kb mRNA species, similar to that present in human decidua, was identified in poly(A)RNA-containing preparations of granulosa cells and of a borderline malignant ovarian cystadenoma. This finding verifies the postulated production of IGF BP-1 by the human ovary.
ISSN:0300-0664
DOI:10.1111/j.1365-2265.1990.tb00907.x