Ruthenium (II)‐Catalyzed Oxidant‐Free Coupling/Cyclization of Benzimidates and Sulfoxonium Ylides to Form Substituted Isoquinolines

A ruthenium‐catalyzed direct mono‐C−H functionalization/annulation cascade reaction of benzimidates and sulfoxonium ylides has been developed. The reaction proceeds smoothly with a broad range of substrates, giving access to a variety of isoquinoline derivatives in moderate to good yields using an o...

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Bibliographic Details
Published inAdvanced synthesis & catalysis Vol. 360; no. 21; pp. 4049 - 4053
Main Authors Shi, Xinxia, Wang, Rongchao, Zeng, Xiaofei, Zhang, Yilan, Hu, Huiling, Xie, Chunsong, Wang, Min
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 05.11.2018
Wiley Subscription Services, Inc
Subjects
Benzimidate
Cascade chemical reactions
Chemical reactions
Chemistry
Chemistry, Applied
Chemistry, Organic
Isoquinoline
Organic chemistry
Oxidant-free
Physical Sciences
Ruthenium
Ruthenium catalyst
Science & Technology
Substrates
Sulfoxonium ylide
CATALYZED OXIDATIVE ANNULATION
Sulfoxonium ylide
ARYLATION
BENZODIAZEPINE-RECEPTORS
Oxidant-free
ALKYNES
C-H ACTIVATION
Benzimidate
Ruthenium catalyst
FUNCTIONALIZATION
AROMATIC AMIDES
Isoquinoline
LIGAND
CYCLIZATION
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Summary:A ruthenium‐catalyzed direct mono‐C−H functionalization/annulation cascade reaction of benzimidates and sulfoxonium ylides has been developed. The reaction proceeds smoothly with a broad range of substrates, giving access to a variety of isoquinoline derivatives in moderate to good yields using an organic acid additive under oxidant free conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800844