Recent Developments in Deaminative Functionalization of Alkyl Amines

The amino group is one of the most prevalent functional groups present in a wide range of organic molecules, which has been widely applied in various organic synthesis and pharmaceuticals. Alkyl amines could be converted in a single step into Katritzky salts which could serve as alkyl radical precur...

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Published inEuropean journal of organic chemistry Vol. 2021; no. 8; pp. 1215 - 1228
Main Authors Li, Yi‐Na, Xiao, Fang, Guo, Yu, Zeng, Yao‐Fu
Format Journal Article
LanguageEnglish
Published Weinheim Wiley Subscription Services, Inc 25.02.2021
Subjects
Alkyl amines
Alkyl radicals
Amines
C(sp3)−N bond cleavage
Catalysis
Deaminative functionalization
Ductile-brittle transition
Functional groups
Katritzky salts
Organic chemistry
Reaction mechanisms
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Summary:The amino group is one of the most prevalent functional groups present in a wide range of organic molecules, which has been widely applied in various organic synthesis and pharmaceuticals. Alkyl amines could be converted in a single step into Katritzky salts which could serve as alkyl radical precursors to construct C−C bonds and C−X bonds via C(sp3)−N cleavage. This deaminative functionalization could be carried out under transition‐metal catalysis, photocatalysis, carbene catalysis or promoted by base. In this paper, recent developments in the deaminative functionalization of alkyl amines were covered. This review was categorized into four parts according to the nature of the bond formation. Some representative examples and corresponding reaction mechanisms were also summarized. Alkyl amines could serve as alkyl radical precursors to construct C−C bonds and C−X bonds via C(sp3)−N cleavage. This review covered recent developments in the deaminative functionalization of alkyl amines.
Bibliography:These authors contributed equally to this work.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202001193