Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures
The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) and matrix‐assisted laser desorption ionization mass spectrometry (AP‐MALDI‐MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization technique...
Saved in:
| Published in | Journal of mass spectrometry. Vol. 40; no. 4; pp. 539 - 545 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.04.2005
Wiley |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) and matrix‐assisted laser desorption ionization mass spectrometry (AP‐MALDI‐MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP‐DIOS‐MS/MS and AP‐MALDI‐MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP‐DIOS‐MS/MS were 1–3 pmol, indicating excellent sensitivity of the method. The LODs with AP‐MALDI‐MS/MS were about 5–10 times higher. Copyright © 2005 John Wiley & Sons, Ltd. |
|---|---|
| AbstractList | Abstract
The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) and matrix‐assisted laser desorption ionization mass spectrometry (AP‐MALDI‐MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP‐DIOS‐MS/MS and AP‐MALDI‐MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP‐DIOS‐MS/MS were 1–3 pmol, indicating excellent sensitivity of the method. The LODs with AP‐MALDI‐MS/MS were about 5–10 times higher. Copyright © 2005 John Wiley & Sons, Ltd. The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) and matrix-assisted laser desorption ionization mass spectrometry (AP-MALDI-MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP-DIOS-MS/MS and AP-MALDI-MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP-DIOS-MS/MS were 1-3 pmol, indicating excellent sensitivity of the method. The LODs with AP-MALDI-MS/MS were about 5-10 times higher. The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) and matrix‐assisted laser desorption ionization mass spectrometry (AP‐MALDI‐MS) for the identification of amphetamines and fentanyls in forensic samples was studied. With both ionization techniques, the mass spectra recorded showed abundant protonated molecules, and the background did not disturb the analysis. The use of tandem mass spectrometry (MS/MS) allowed unambiguous identification of the amphetamines and fentanyls. AP‐DIOS‐MS/MS and AP‐MALDI‐MS/MS were also successfully applied to the identification of authentic compounds from drug seizures. Common diluents and tablet materials did not disturb the analysis and compounds were unequivocally identified. The limits of detection (LODs) for amphetamines and fentanyls with AP‐DIOS‐MS/MS were 1–3 pmol, indicating excellent sensitivity of the method. The LODs with AP‐MALDI‐MS/MS were about 5–10 times higher. Copyright © 2005 John Wiley & Sons, Ltd. |
| Author | Franssila, Sami Grigoras, Kestutis Pihlainen, Katja Kotiaho, Tapio Kostiainen, Risto Ketola, Raimo |
| Author_xml | – sequence: 1 givenname: Katja surname: Pihlainen fullname: Pihlainen, Katja organization: University of Helsinki, Division of Pharmaceutical Chemistry, Department of Pharmacy, P.O. Box 56, FIN-00014 Helsinki, Finland – sequence: 2 givenname: Kestutis surname: Grigoras fullname: Grigoras, Kestutis organization: Microelectronics Centre, Helsinki University of Technology, P.O. Box 3000, FIN-02015 HUT, Finland – sequence: 3 givenname: Sami surname: Franssila fullname: Franssila, Sami organization: Microelectronics Centre, Helsinki University of Technology, P.O. Box 3000, FIN-02015 HUT, Finland – sequence: 4 givenname: Raimo surname: Ketola fullname: Ketola, Raimo organization: Viikki Drug Discovery Technology Center DDTC, Department of Pharmacy, P.O. Box 56, FIN-00014 Helsinki, Finland – sequence: 5 givenname: Tapio surname: Kotiaho fullname: Kotiaho, Tapio organization: Viikki Drug Discovery Technology Center DDTC, Department of Pharmacy, P.O. Box 56, FIN-00014 Helsinki, Finland – sequence: 6 givenname: Risto surname: Kostiainen fullname: Kostiainen, Risto email: risto.kostiainen@helsinki.fi organization: University of Helsinki, Division of Pharmaceutical Chemistry, Department of Pharmacy, P.O. Box 56, FIN-00014 Helsinki, Finland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16737278$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15712357$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc1u1TAQhSNURH9AvAHyBligtHZix8myraCAWpAoCImNNdeZgEviBI-vaPrOvAO-5IqyoJKtGcmfzpzx2c92_Ogxyx4Lfig4L46uBjqsS3Ev2xO8qfKmruudTa-rXAktd7N9oivOedPI6kG2K5QWRan0Xvbr2EM_kyM2dgyG6RtGGJxHYuBb1qGP4Oee2GpmEIeREhCcZVNAonVA1iKNYYpu9EfpuhvYtCwdcr2zqQ5AxGhCG8M4YAzzH-EBYnDXeXpzFLFlPRCGO8T-r-BisjhNachCxZF1Y0BPyR38s1Mb1l8ZobtJbulhdr-DnvDRth5kn169_Hj6Oj9_f_bm9Pg8t2X6xRxVUwjVdFh3ui5avmrlCrS2Wkre2q4oJMIKFUqhasFTAFVpQUmJZQNSYVceZM8W3SmMP9ZI0QyOLPY9eBzXZCqtayGLJoHPF9CGkShgZ6bgBgizEdxskjUpWZM8JfLJVnK9GrC95bZRJuDpFgCy0HcBvHV0y1W61IWuE_di4X66Hue75pm3F5fL2HyhNzld_6UhfDcbQWU-vzszX8oTdVlffDCX5W8NstPz |
| CitedBy_id | crossref_primary_10_1002_jms_1628 crossref_primary_10_1016_j_cossms_2006_03_004 crossref_primary_10_1002_dta_2758 crossref_primary_10_2217_nnm_10_127 crossref_primary_10_1002_elps_201200270 crossref_primary_10_1007_s00216_010_4063_3 crossref_primary_10_1002_dta_1419 crossref_primary_10_1002_elps_201100655 crossref_primary_10_1021_ac0706170 crossref_primary_10_1021_ac802176j crossref_primary_10_1016_j_chroma_2006_01_071 crossref_primary_10_1002_rcm_3550 crossref_primary_10_1016_j_ijms_2019_116253 crossref_primary_10_1016_j_talanta_2014_09_040 crossref_primary_10_1039_b703524a crossref_primary_10_1021_ac061154l crossref_primary_10_1002_mas_20104 crossref_primary_10_1002_jssc_201200480 crossref_primary_10_1002_jssc_201801098 crossref_primary_10_1007_s00414_014_1040_y crossref_primary_10_1080_10826070701191151 crossref_primary_10_1002_jms_807 crossref_primary_10_1039_c2cp00038e crossref_primary_10_1016_j_ijms_2013_09_016 crossref_primary_10_1002_jms_1385 crossref_primary_10_1255_ejms_761 crossref_primary_10_1002_rcm_4673 |
| Cites_doi | 10.1016/S0003-2670(01)01107-2 10.1093/jat/23.4.280 10.1002/jms.237 10.1016/S1387-3806(02)00972-7 10.1016/S0731-7085(03)00110-9 10.1016/S1387-3806(02)00893-X 10.1021/ac00024a716 10.1021/ac990998k 10.1016/0379-0738(89)90117-5 10.1021/ac026253n 10.1039/B207634A 10.1038/20400 10.1021/jm00256a003 10.1093/jat/27.2.78 10.1002/jms.631 10.1016/S1570-0232(02)00400-2 10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3 10.1016/j.chroma.2003.12.073 10.1021/ac00250a016 10.1248/cpb.34.1340 10.1021/ac00171a028 10.1002/rcm.255 10.1016/S1570-0232(01)00569-4 10.1002/rcm.1051 10.1002/rcm.781 10.1520/JFS12283J 10.1073/pnas.081069298 10.1016/S0731-7085(03)00652-6 |
| ContentType | Journal Article |
| Copyright | Copyright © 2005 John Wiley & Sons, Ltd. 2005 INIST-CNRS Copyright 2005 John Wiley & Sons, Ltd. |
| Copyright_xml | – notice: Copyright © 2005 John Wiley & Sons, Ltd. – notice: 2005 INIST-CNRS – notice: Copyright 2005 John Wiley & Sons, Ltd. |
| DBID | BSCLL IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1002/jms.831 |
| DatabaseName | Istex Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1096-9888 |
| EndPage | 545 |
| ExternalDocumentID | 10_1002_jms_831 15712357 16737278 JMS831 ark_67375_WNG_Z3B5S8MR_S |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: National Technology Agency of Finland. – fundername: Jenny and Antti Wihuri Foundation. |
| GroupedDBID | --- -~X .3N .GA .GJ .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5GY 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHBH AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABIJN ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACNCT ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADEOM ADIZJ ADKYN ADMGS ADOZA ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHMBA AI. AITYG AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AQPKS ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BNHUX BROTX BRXPI BSCLL BY8 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM DU5 EBD EBS EJD F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.T H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RNS ROL RWI RX1 RYL SAMSI SUPJJ TN5 TUS UB1 UQL V2E VH1 W8V W99 WBFHL WBKPD WIB WIH WIK WJL WOHZO WQJ WRC WRJ WXSBR WYISQ XG1 XPP XV2 ZCG ZZTAW ~02 ~IA ~KM ~WT 08R ABHUG ACSMX ACXME ADAWD ADDAD AFVGU AGJLS IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c3831-e592159fe8f782d0bd4ba77c7440dcf224eabe5e41581010063ca544e39a45ef3 |
| IEDL.DBID | DR2 |
| ISSN | 1076-5174 |
| IngestDate | Fri Aug 16 05:02:11 EDT 2024 Fri Aug 23 03:47:10 EDT 2024 Sat Sep 28 07:53:05 EDT 2024 Sun Oct 22 16:06:57 EDT 2023 Sat Aug 24 00:50:14 EDT 2024 Wed Oct 30 09:52:58 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Amphetamine derivatives Criminalistics Agonist Atmospheric pressure Psychotropic μ Opioid receptor Fentanyl Opiates Forensic aspect Matrix assisted laser desorption ionization Narcotic analgesic forensic Porous material Desorption ionization on porous silicon Laser desorption atmospheric pressure matrix-assisted laser desorption/ionization atmospheric pressure desorption/ionization on silicon Piperidine derivatives Amfetamine Silicon Drug of abuse Drug Forensic science CNS stimulant 1-(2-phenethyl)-4-N-propionylanilinopiperidine amphetamines Analysis method Mass spectrometry MS/MS Mass spectrometry |
| Language | English |
| License | CC BY 4.0 Copyright 2005 John Wiley & Sons, Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3831-e592159fe8f782d0bd4ba77c7440dcf224eabe5e41581010063ca544e39a45ef3 |
| Notes | ark:/67375/WNG-Z3B5S8MR-S National Technology Agency of Finland. Jenny and Antti Wihuri Foundation. istex:F4C14C22B2C14DEF8DED27352255F9FA23354E2E ArticleID:JMS831 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 15712357 |
| PQID | 67781429 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_67781429 crossref_primary_10_1002_jms_831 pubmed_primary_15712357 pascalfrancis_primary_16737278 wiley_primary_10_1002_jms_831_JMS831 istex_primary_ark_67375_WNG_Z3B5S8MR_S |
| PublicationCentury | 2000 |
| PublicationDate | April 2005 |
| PublicationDateYYYYMMDD | 2005-04-01 |
| PublicationDate_xml | – month: 04 year: 2005 text: April 2005 |
| PublicationDecade | 2000 |
| PublicationPlace | Chichester, UK |
| PublicationPlace_xml | – name: Chichester, UK – name: Chichester – name: England |
| PublicationTitle | Journal of mass spectrometry. |
| PublicationTitleAlternate | J. Mass Spectrom |
| PublicationYear | 2005 |
| Publisher | John Wiley & Sons, Ltd Wiley |
| Publisher_xml | – name: John Wiley & Sons, Ltd – name: Wiley |
| References | Laiko VV, Taranenko NI, Berkout VD, Musselman BD, Doroshenko VM. Atmospheric pressure laser desorption/ionization on porous silicon. Rapid Commun. Mass Spectrom. 2002; 16: 1797. Ohta H, Suzuki S, Ogasawara K. Studies on fentanyl and related compounds IV. Chromatographic and spectrometric discrimination of fentanyl and its derivatives. J. Anal. Toxicol. 1999; 23: 280. Shou WZ, Jiang X, Beato BD, Naidong W. A highly automated 96-well solid phase extraction and liquid chromatography/tandem mass spectrometry method for the determination of fentanyl in human plasma. Rapid Commun. Mass Spectrom. 2001; 15: 466. Cooper D, Jacob M, Allen A. Identification of fentanyl derivatives. J. Forensic Sci. 1986; 31: 511. Go EP, Prenni JE, Wei J, Jones A, Hall SC, Witkowska HE, Shen Z, Siuzdak G. Desorption/ionization on silicon time-of-flight/time-of-light mass spectrometry. Anal. Chem. 2003; 75: 2504. Suzuki S, Inoue T, Kashima C. Studies on 1-(2-phenethyl)-4-N-propionylanilino)piperidine (fentanyl) and related compounds. I. Spectrometric and chromatographic analyses of 3-methylfentanyl and α-methylfentanyl. Chem. Pharm. Bull. 1986; 34: 1340. Wei J, Jillian M, Siuzdak G. Desorption/ionization on silicon time-of-flight/time-of-flight mass spectrometry. Nature 1999; 399: 243. Borth S, Hänsel W, Rösner P, Junge T. Regioisomeric differentiation of 2,3- and 3,4-methylenedioxy ring-substituted phenylalkylamines by gas chromatography/tandem mass spectrometry. J. Mass Spectrom. 2000; 35: 705. Hillenkamp F, Karas M, Beavis RC, Chait BT. Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers. Anal. Chem. 1991; 63: 1193A. Arakawa R, Shimomae Y, Morikawa H, Ohara K, Okuno S. Mass spectrometric analysis of low molecular mass polyesters by laser desorption/ionization on porous silicon. J. Mass Spectrom. 2004; 39: 961. Palleschi L, Lucentini L, Ferretti E, Anastasi F, Amoroso M, Draisci G. Quantitative determination of sufentanil in human plasma by liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2003; 32: 329. Thomas JJ, Shen Z, Blackledge R, Siuzdak G. Desorption-ionization on silicon mass spectrometry: an application in forensics. Anal. Chim. Acta 2001; 442: 183. Wood M, De Boeck G, Samyn N, Morris M, Cooper DP, Maes RAA, De Bruijn EA. Development of a rapid and sensitive method for the quantitation of amphetamines in human plasma and oral fluid by LC-MS-MS. J. Anal. Toxicol. 2003; 27: 78. Pihlainen K, Kostiainen R. Effect of the eluent on enantiomer separation of controlled drugs by liquid chromatography-ultraviolet absorbance detection-electrospray ionisation tandem mass spectrometry using vancomycin and native β-cyclodextrin chiral stationary phases. J. Chromatogr. A 2004; 1033: 91. Karas M, Hillenkamp F. Laser desorption ionization of proteins with molecular masses exceeding 10 000 Daltons. Anal. Chem. 1988; 60: 2299. Moyer SC, Marzilli LA, Woods AS, Laiko VV, Doroshenko VM, Cotter RJ. Atmospheric pressure MALDI on a quadrupole ion trap mass spectrometer. Int. J. Mass Spectrom. 2003; 226: 133. Tuomikoski S, Huikko K, Grigoras K, Östman P, Kostiainen R, Baumann M, Abian J, Kotiaho T, Franssila S. Preparation of porous n-type silicon samples for desorption/ionization on silicon MS (DIOS-MS). Lab Chip 2002; 2: 247. Laiko VV, Baldwin MA, Burlingame AL. Atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Anal. Chem. 2000; 72: 652. Huikko K, Östman P, Sauber C, Mandel F, Grigoras K, Franssila S, Kotiaho T, Kostiainen R. Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs. Rapid Commun. Mass Spectrom. 2003; 17: 1339. Rausberg P. Analysis of fentanyl and 3-methylfentanyl in seized samples performed in Estonian forensic service center. In Proceedings of the 3rd European Academy of Forensic Science Meeting, September 22-27, 2003, Istanbul, Turkey. Forensic Sci. Int. 2003; 136: 96. Marten-Lobenhoffer J. Very sensitive and specific determination of sufentanil in human serum applying liquid chromatography-two stage mass spectrometry. J. Chromatogr. B 2002; 769: 227. Doroshenko VM, Laiko VV, Taranenko NI, Berkout VD, Lee HS. Recent developments in atmospheric pressure MALDI mass spectrometry. Int. J. Mass Spectrom. 2002; 221: 39. Van Bever WFM, Niemegeers CJE, Janssen PAJ. Synthetic analgesics: synthesis and pharmacology of the diastereomers of N-[3-methyl-1-(2-phenylthyl)-4-piperidyl]-N-phenylpropanamide and N-[3-methyl-1-(1-methyl-2-phenethyl) -4-piperidyl]-N-phenylpropanamide. J. Med. Chem. 1974; 17: 1047. Cheng MT, Kruppa GH, McLafferty FW, Cooper DA. Structural information from mass spectrometry for China White and related fentanyl derivatives. Anal. Chem. 1982; 54: 2204. Suzuki S. Studies on fentanyl related compounds II. Spectrometric discrimination of five mono methylated fentanyl isomers by gas chromatography/Fourier transform-infrared spectrometry. Forensic Sci. Int. 1989; 43: 15. Shen Z, Thomas JJ, Averbuj C, Klas M, Engelhard M, Crowell JE, Finn MG, Siuzdak G. Porous silicon as a versatile platform for laser desorption/ionization mass spectrometry. Anal. Chem. 2001; 33: 179. Koch DE, Isaza R, Carpenter J, Hunter RP. Simultaneous extraction and quantitation of fentanyl and norfentanyl from primate plasma with LC/MS detection. J. Pharm. Biomed. Anal. 2004; 34: 577. Mortier KA, Maudens KE, Lambert WE, Clauwaert KM, van Bocxlaer JF, Deforce DL, Van Peteghem CH, De Leenheer AP. Simultaneous, quantitative determination of opiates, amphetamines, cocaines and benzoylecgonine in oral fluid by liquid chromatography quadrupole-time-of-flight mass spectrometry. J. Chromatogr. B 2002; 779: 321. Kruse RA, Rubakhin SS, Romanova EV, Bohn PW, Sweedler JV. Direct assay of Aplysia tissues and cells with laser desorption/ionization mass spectrometry on porous silicon. J. Mass Spectrom. 2001; 36: 1217. Thomas JJ, Shen Z, Crowell JE, Finn MG, Siuzdak G. Desorption/ionization on silicon (DIOS): a diverse mass spectrometry platform for protein characterization. Proc. Natl. Acad. Sci. USA 2001; 98: 4932. 2002; 16 2001; 442 1989; 43 1986; 31 1986; 34 1982; 54 2000; 72 1999; 23 2002; 2 2003; 17 2003 2002; 779 2003; 136 2003; 75 2003; 32 1974; 17 2003; 226 2004; 39 2000; 35 1991; 63 2004; 34 2002; 221 2003; 27 2001; 15 1999; 399 2004; 1033 2002; 769 2001; 33 1988; 60 2001; 36 2001; 98 e_1_2_6_31_2 e_1_2_6_30_2 e_1_2_6_19_2 e_1_2_6_12_2 e_1_2_6_13_2 e_1_2_6_10_2 Shen Z (e_1_2_6_18_2) 2001; 33 e_1_2_6_11_2 e_1_2_6_16_2 e_1_2_6_17_2 e_1_2_6_14_2 e_1_2_6_15_2 e_1_2_6_20_2 e_1_2_6_8_2 e_1_2_6_7_2 e_1_2_6_9_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_6_2 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 e_1_2_6_22_2 e_1_2_6_21_2 e_1_2_6_28_2 e_1_2_6_27_2 e_1_2_6_26_2 e_1_2_6_25_2 Rausberg P. (e_1_2_6_32_2) 2003; 136 |
| References_xml | – volume: 17 start-page: 1047 year: 1974 article-title: Synthetic analgesics: synthesis and pharmacology of the diastereomers of ‐[3‐methyl‐1‐(2‐phenylthyl)‐4‐piperidyl]‐ ‐phenylpropanamide and ‐[3‐methyl‐1‐(1‐methyl‐2‐phenethyl) ‐4‐piperidyl]‐ ‐phenylpropanamide publication-title: J. Med. Chem. – volume: 75 start-page: 2504 year: 2003 article-title: Desorption/ionization on silicon time‐of‐flight/time‐of‐light mass spectrometry publication-title: Anal. Chem. – volume: 98 start-page: 4932 year: 2001 article-title: Desorption/ionization on silicon (DIOS): a diverse mass spectrometry platform for protein characterization publication-title: Proc. Natl. Acad. Sci. USA – volume: 36 start-page: 1217 year: 2001 article-title: Direct assay of Aplysia tissues and cells with laser desorption/ionization mass spectrometry on porous silicon publication-title: J. Mass Spectrom. – volume: 63 start-page: 1193A year: 1991 article-title: Matrix‐assisted laser desorption/ionization mass spectrometry of biopolymers publication-title: Anal. Chem. – volume: 33 start-page: 179 year: 2001 article-title: Porous silicon as a versatile platform for laser desorption/ionization mass spectrometry publication-title: Anal. Chem. – volume: 442 start-page: 183 year: 2001 article-title: Desorption–ionization on silicon mass spectrometry: an application in forensics publication-title: Anal. Chim. Acta – volume: 769 start-page: 227 year: 2002 article-title: Very sensitive and specific determination of sufentanil in human serum applying liquid chromatography–two stage mass spectrometry publication-title: J. Chromatogr. B – volume: 43 start-page: 15 year: 1989 article-title: Studies on fentanyl related compounds II. Spectrometric discrimination of five mono methylated fentanyl isomers by gas chromatography/Fourier transform‐infrared spectrometry publication-title: Forensic Sci. Int. – volume: 226 start-page: 133 year: 2003 article-title: Atmospheric pressure MALDI on a quadrupole ion trap mass spectrometer publication-title: Int. J. Mass Spectrom. – volume: 39 start-page: 961 year: 2004 article-title: Mass spectrometric analysis of low molecular mass polyesters by laser desorption/ionization on porous silicon publication-title: J. Mass Spectrom. – volume: 1033 start-page: 91 year: 2004 article-title: Effect of the eluent on enantiomer separation of controlled drugs by liquid chromatography–ultraviolet absorbance detection–electrospray ionisation tandem mass spectrometry using vancomycin and native β‐cyclodextrin chiral stationary phases publication-title: J. Chromatogr. A – volume: 23 start-page: 280 year: 1999 article-title: Studies on fentanyl and related compounds IV. Chromatographic and spectrometric discrimination of fentanyl and its derivatives publication-title: J. Anal. Toxicol. – volume: 54 start-page: 2204 year: 1982 article-title: Structural information from mass spectrometry for China White and related fentanyl derivatives publication-title: Anal. Chem. – volume: 15 start-page: 466 year: 2001 article-title: A highly automated 96‐well solid phase extraction and liquid chromatography/tandem mass spectrometry method for the determination of fentanyl in human plasma publication-title: Rapid Commun. Mass Spectrom. – volume: 34 start-page: 1340 year: 1986 article-title: Studies on 1‐(2‐phenethyl)‐4‐ ‐propionylanilino)piperidine (fentanyl) and related compounds. I. Spectrometric and chromatographic analyses of 3‐methylfentanyl and α‐methylfentanyl publication-title: Chem. Pharm. Bull. – volume: 31 start-page: 511 year: 1986 article-title: Identification of fentanyl derivatives publication-title: J. Forensic Sci. – volume: 27 start-page: 78 year: 2003 article-title: Development of a rapid and sensitive method for the quantitation of amphetamines in human plasma and oral fluid by LC‐MS‐MS publication-title: J. Anal. Toxicol. – volume: 399 start-page: 243 year: 1999 article-title: Desorption/ionization on silicon time‐of‐flight/time‐of‐flight mass spectrometry publication-title: Nature – volume: 72 start-page: 652 year: 2000 article-title: Atmospheric pressure matrix‐assisted laser desorption/ionization mass spectrometry publication-title: Anal. Chem. – volume: 34 start-page: 577 year: 2004 article-title: Simultaneous extraction and quantitation of fentanyl and norfentanyl from primate plasma with LC/MS detection publication-title: J. Pharm. Biomed. Anal. – volume: 779 start-page: 321 year: 2002 article-title: Simultaneous, quantitative determination of opiates, amphetamines, cocaines and benzoylecgonine in oral fluid by liquid chromatography quadrupole‐time‐of‐flight mass spectrometry publication-title: J. Chromatogr. B – volume: 32 start-page: 329 year: 2003 article-title: Quantitative determination of sufentanil in human plasma by liquid chromatography–tandem mass spectrometry publication-title: J. Pharm. Biomed. Anal. – volume: 16 start-page: 1797 year: 2002 article-title: Atmospheric pressure laser desorption/ionization on porous silicon publication-title: Rapid Commun. Mass Spectrom. – volume: 60 start-page: 2299 year: 1988 article-title: Laser desorption ionization of proteins with molecular masses exceeding 10 000 Daltons publication-title: Anal. Chem. – volume: 17 start-page: 1339 year: 2003 article-title: Feasibility of atmospheric pressure desorption/ionization on silicon mass spectrometry in analysis of drugs publication-title: Rapid Commun. Mass Spectrom. – volume: 136 start-page: 96 year: 2003 article-title: Analysis of fentanyl and 3‐methylfentanyl in seized samples performed in Estonian forensic service center. In Proceedings of the 3rd European Academy of Forensic Science Meeting, September 22–27, 2003, Istanbul, Turkey publication-title: Forensic Sci. Int. – volume: 2 start-page: 247 year: 2002 article-title: Preparation of porous n‐type silicon samples for desorption/ionization on silicon MS (DIOS‐MS) publication-title: Lab Chip – start-page: 1 year: 2003 – volume: 221 start-page: 39 year: 2002 article-title: Recent developments in atmospheric pressure MALDI mass spectrometry publication-title: Int. J. Mass Spectrom. – volume: 35 start-page: 705 year: 2000 article-title: Regioisomeric differentiation of 2,3‐ and 3,4‐methylenedioxy ring‐substituted phenylalkylamines by gas chromatography/tandem mass spectrometry publication-title: J. Mass Spectrom. – ident: e_1_2_6_19_2 doi: 10.1016/S0003-2670(01)01107-2 – ident: e_1_2_6_2_2 – ident: e_1_2_6_4_2 doi: 10.1093/jat/23.4.280 – ident: e_1_2_6_20_2 doi: 10.1002/jms.237 – ident: e_1_2_6_26_2 doi: 10.1016/S1387-3806(02)00972-7 – ident: e_1_2_6_13_2 doi: 10.1016/S0731-7085(03)00110-9 – ident: e_1_2_6_28_2 doi: 10.1016/S1387-3806(02)00893-X – ident: e_1_2_6_16_2 doi: 10.1021/ac00024a716 – ident: e_1_2_6_24_2 doi: 10.1021/ac990998k – volume: 33 start-page: 179 year: 2001 ident: e_1_2_6_18_2 article-title: Porous silicon as a versatile platform for laser desorption/ionization mass spectrometry publication-title: Anal. Chem. contributor: fullname: Shen Z – ident: e_1_2_6_5_2 doi: 10.1016/0379-0738(89)90117-5 – ident: e_1_2_6_22_2 doi: 10.1021/ac026253n – ident: e_1_2_6_27_2 doi: 10.1039/B207634A – ident: e_1_2_6_17_2 doi: 10.1038/20400 – ident: e_1_2_6_3_2 doi: 10.1021/jm00256a003 – ident: e_1_2_6_10_2 doi: 10.1093/jat/27.2.78 – ident: e_1_2_6_29_2 doi: 10.1002/jms.631 – ident: e_1_2_6_9_2 doi: 10.1016/S1570-0232(02)00400-2 – ident: e_1_2_6_30_2 doi: 10.1002/1096-9888(200006)35:6<705::AID-JMS997>3.0.CO;2-3 – ident: e_1_2_6_11_2 doi: 10.1016/j.chroma.2003.12.073 – ident: e_1_2_6_8_2 doi: 10.1021/ac00250a016 – ident: e_1_2_6_6_2 doi: 10.1248/cpb.34.1340 – ident: e_1_2_6_15_2 doi: 10.1021/ac00171a028 – ident: e_1_2_6_12_2 doi: 10.1002/rcm.255 – ident: e_1_2_6_31_2 doi: 10.1016/S1570-0232(01)00569-4 – ident: e_1_2_6_23_2 doi: 10.1002/rcm.1051 – ident: e_1_2_6_25_2 doi: 10.1002/rcm.781 – volume: 136 start-page: 96 year: 2003 ident: e_1_2_6_32_2 article-title: Analysis of fentanyl and 3‐methylfentanyl in seized samples performed in Estonian forensic service center. In Proceedings of the 3rd European Academy of Forensic Science Meeting, September 22–27, 2003, Istanbul, Turkey publication-title: Forensic Sci. Int. contributor: fullname: Rausberg P. – ident: e_1_2_6_7_2 doi: 10.1520/JFS12283J – ident: e_1_2_6_21_2 doi: 10.1073/pnas.081069298 – ident: e_1_2_6_14_2 doi: 10.1016/S0731-7085(03)00652-6 |
| SSID | ssj0009946 |
| Score | 1.9731631 |
| Snippet | The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) and matrix‐assisted laser desorption ionization mass... The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP-DIOS-MS) and matrix-assisted laser desorption ionization mass... Abstract The suitability of atmospheric pressure desorption/ionization on silicon mass spectrometry (AP‐DIOS‐MS) and matrix‐assisted laser desorption... |
| SourceID | proquest crossref pubmed pascalfrancis wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 539 |
| SubjectTerms | 1-(2-phenethyl)-4-N-propionylanilino)piperidine amphetamines Amphetamines - analysis Amphetamines - chemistry Analysis Atmospheric Pressure atmospheric pressure desorption/ionization on silicon atmospheric pressure matrix-assisted laser desorption/ionization Biological and medical sciences fentanyl Fentanyl - analysis Fentanyl - chemistry forensic Forensic Sciences - methods General pharmacology Mass Spectrometry Medical sciences Molecular Structure Neuropharmacology Pharmacology. Drug treatments Powders - chemistry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Sensitivity and Specificity Silicon - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Tablets - chemistry |
| Title | Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures |
| URI | https://api.istex.fr/ark:/67375/WNG-Z3B5S8MR-S/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjms.831 https://www.ncbi.nlm.nih.gov/pubmed/15712357 https://search.proquest.com/docview/67781429 |
| Volume | 40 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbpwwELaq9NBe-v9D_upD1Bu72QWv4dgkTaNIm0O2UaNcLGPsaJsAFQYpyamP0GfsC_QVOmMvoVslUlWExMHYDOYb-ICZbwjZGsk4l7CAi49lCJ5oQsm2s1DJSEvAiJ44AdPp0eTgJD48Zad_lPry-hC3H9zQM9z9Gh1cZnbYi4Z-LewgcRnUo4hjMNfecS8claY-rwje0kPUYvbpsthzuOi39Bx6iFN6hXGR0sLUGF_T4i7Sucxh3UNo_yk568z3sScXg7bJBurmL2XH_zq_Z-TJgprSDx5Lz8kDXb4gj3a7inAvya9OwYRWhkqAgW5kgWHzVJY5NRiFXl5fWppdU9kUlUXFgrmiLtS2rTXNta1qd4sa4ldgnwBKYbXzSwBkSQtg8tTlfqKIAhzTDVxgFYGrn99_QCvOYE6B8ev6nuHuHmPegJH9v3raVBTYOgbvK2jvzyqv23Nq9fwG7LWvyMn-x8-7B-GiYESo4EV7FGqWAoNJjU4MEJ98O8vjTHKuUAQxVwbYipaZZhpIC-qaIT1TksWxjlIZM22i12SlrEr9ltCEMa4nwH0MV7FC9eYxlwDgbMyTPI1NQGgHH_HN64IIrwA9FnDlBJgTkPcOVrftsr7AMDrOxJejT-Is2mGzZHosZgHZXMJdP6ArIsSTgLzrgCjgkuMvHVnqqrUC5f9GQCkC8sbjs-_LOKZB84BsOZTdZ6U4nM5gs_pvu62Rx0671oUurZOVpm71BrCyJtt0Dvgb_sg_MQ |
| link.rule.ids | 315,783,787,1378,27938,27939,46308,46732 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LTtwwFLUQLOimL_pIH-AFYpcZZhKPk2VLSwfKzIIBFbULy3HsagpJqjwkYNVP6Df2B_oLvdeeEE0FUtUoUhaOHds5Nzlx7j2XkO2BDFMJG5j4UPpgicaXbDfxlQy0BIzokRUwnUxH49Pw8IydLbwqMRbG6UPcLLihZdjnNRo4Lkj3O9XQb1nVizCEeg0uEWD2gnfHnXRUHLvIIvhO91GN2QXMYtX-ouLSm2gNJ_USPSNlBZNjXFaL22jnMou1r6H9B-RLOwDnfXLea-qkp67_0nb8vxE-JPcX7JS-cXB6RFZ0_pis77VJ4TbI71bEhBaGSkCCrmWGnvNU5ik16IieX11UNLmiss6KCkUL5opab9um1DTVVVHap1QfF4JdDCiFvZpfACZzmgGZpzb8E3UU4Jq24QwTCVz--vETSnEKUwqkX5d3NHd7G_MaOtn9rqd1QYGwo_--gvJuVGnZfKWVnl9Df6sn5HT__cne2F_kjPAVfGsPfM1iIDGx0ZEB7pPuJmmYSM4V6iCmygBh0TLRTANvQWkzZGhKsjDUQSxDpk3wlKzmRa6fExoxxvUI6I_hKlQo4DzkEjCcDHmUxqHxCG3xI747aRDhRKCHAu6cgO54ZMfi6qZclufoSceZ-DT9ID4Hb9ksmhyLmUc2l4DXNWjzCPHII1stEgXccvyrI3NdNJVABcABsAqPPHMA7eoyjpHQ3CPbFmZ39VIcTmZwePFvp22R9fHJ5EgcHUw_viT3rJSt9WR6RVbrstGvgaTVyaa1xj-apkNL |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtRAEG2hRAIu7ItZkj5E3Dyb3dP2ERKGEJgRyhAR5dJq94KGxHbkRUpy4hP4Rn6AX6CqPY4ZlEgIy5IP7W6X26_sZ7vqFSFbQxlqCQu4-Ej64InWl2yQ-EoGRgJGzNgJmE5n492DcO-QHf5R6qvRh7j84Iae4e7X6OCn2vY70dBvadmLMIN6PRwHA4zm2tnvlKPiuEksgtd0H8WYm3xZ7Npfdlx5EK3jnJ5hYKQsYW5sU9TiKta5SmLdU2hylxy19jfBJ8e9ukp66uIvacf_OsF75M6Sm9LXDZjukxsme0Bubbcl4R6SX62ECc0tlYADU8kU4-apzDS1GIaenZ-UNDmnskrzEiULFoq6WNu6MFSbMi_cPaqPn4GbDFAKa7k4AURmNAUqT13yJ6oowDHdwCmWETj7-f0HtOIMagqU3xTXDHf1GIsKjOx-1tMqp0DXMXpfQXt3Vrqov9LSLC7A3vIROZi8_by96y8rRvgK3rSHvmExUJjYmsgC89GDRIeJ5FyhCqJWFuiKkYlhBlgLCpshP1OShaEJYhkyY4PHZC3LM_OU0IgxbsZAfixXoUL55hGXgOBkxCMdh9YjtIWPOG2EQUQjAT0ScOUEmOORVw5Wl-2yOMY4Os7El9k7cRS8YfNoui_mHtlYwV03oKsixCOPbLZAFHDJ8Z-OzExelwL1_4bAKTzypMFn15dxzIPmHtlyKLvOSrE3ncPm2b_ttkluftqZiI_vZx-ek9tOx9aFMb0ga1VRm5fA0Kpkw_nib8ENQfo |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Analysis+of+amphetamines+and+fentanyls+by+atmospheric+pressure+desorption%2Fionization+on+silicon+mass+spectrometry+and+matrix%E2%80%90assisted+laser+desorption%2Fionization+mass+spectrometry+and+its+application+to+forensic+analysis+of+drug+seizures&rft.jtitle=Journal+of+mass+spectrometry.&rft.au=Pihlainen%2C+Katja&rft.au=Grigoras%2C+Kestutis&rft.au=Franssila%2C+Sami&rft.au=Ketola%2C+Raimo&rft.date=2005-04-01&rft.issn=1076-5174&rft.eissn=1096-9888&rft.volume=40&rft.issue=4&rft.spage=539&rft.epage=545&rft_id=info:doi/10.1002%2Fjms.831&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_jms_831 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1076-5174&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1076-5174&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1076-5174&client=summon |