Core-Shell Nanocapsules Stabilized by Single-Component Polymer and Nanoparticles for Magneto-Chemotherapy/Hyperthermia with Multiple Drugs

• Published in: Advanced materials (Weinheim) Vol. 24; no. 27; pp. 3627 - 3632
• Main Authors: Hu, Shang-Hsiu, Liao, Bang-Jie, Chiang, Chin-Sheng, Chen, Po-Jung, Chen, I-Wei, Chen, San-Yuan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 17.07.2012; WILEY‐VCH Verlag
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Cell Line, Tumor; double emulsions; Doxorubicin - administration & dosage; Emulsions - chemistry; Ferric Compounds - chemistry; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; hyperthermia; Hyperthermia, Induced; iron oxide nanoparticles; Magnetic Fields; Mice; nanocapsules; Nanocapsules - chemistry; Nanoparticles - chemistry; Neoplasms - drug therapy; Paclitaxel - administration & dosage; Polymers - chemistry; synergic therapy; Transplantation, Heterologous
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.201201251

Iron‐oxide‐containing double emulsion capsules carrying both hydrophilic and hydrophobic therapeutic molecules can deliver drugs and energy on demand in vivo. Magneto‐chemotherapy/hyperthermia involves a burst‐like release of hydrophilic doxorubicin and hydrophobic paclitaxel, remotely triggered by a high frequency magnetic field, which also releases energy via internalized iron oxide nanoparticles, all contributing to cell kill.